Skip to main content

Barrett, The Honors College Thesis/Creative Project Collection


Barrett, the Honors College accepts high performing, academically engaged students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project, supervised and defended in front of a faculty committee. The thesis or creative project allows students to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is a student’s opportunity to explore areas of academic interest with greater intensity than is possible in a single course. It is also an opportunity to engage with professors, nationally recognized in their fields and specifically interested and committed to working with honors students. This work provides tangible evidence of a student’s research, writing and creative skills to graduate schools and/or prospective employers.


Contributor
Date Range
2012 2018


Previously we found that the serotonin 1B receptor (5-HT1BR) agonist CP 94,253 (CP) enhances the reinforcing properties of cocaine when given to male rats self-administering the drug daily, however, CP had the opposite effect following a 21-day period of abstinence. Methamphetamine, like cocaine, has similar mechanisms of action on the monoamine neurotransmitter systems. Therefore, we predicted that CP would have effects on the reinforcing properties of methamphetamine similar to cocaine. Additionally, we examined effects of the FDA-approved 5-HT1B/DR agonist, zolmitriptan, on psychostimulant self-administration. We first tested the effects of CP on methamphetamine self-administration utilizing a fixed ratio or progressive ratio ...

Contributors
Cotter, Austin Richard, Neisewander, Janet, Newbern, Jason, et al.
Created Date
2018-05

Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell ...

Contributors
Ghorayeb, Antoine, Neisewander, Janet, Diehnelt, Chris, et al.
Created Date
2012-12

The human hairless gene (HR) encodes a 130 kDa transcription factor that is primarily expressed in the brain and skin. In the promoter and 5’-untranslated regions (5’-UTR) of HR, there are three putative consensus p53 responsive elements (p53RE). p53 is a tumor suppressor protein that regulates cell proliferation, apoptosis, and other cell functions. The p53 protein, a known tumor suppressor, acts as a transcription factor and binds to DNA p53REs to activate or repress transcription of the target gene. In general, the p53 binding sequence is 5’-RRRCWWGYYY-3’ where W is A or T, and R and Y are purines or ...

Contributors
Maatough, Anas, Neisewander, Janet, Hsieh, Jui-Cheng, et al.
Created Date
2018-05

Abstract Cocaine is highly addictive because it exacerbates the action responsible for creating the feeling of “reward,” which is controlled by the neurotransmitter dopamine. Dopamine receptors can be divided into five subtypes: D1, D2, D3, D4, and D5. The localization of D3 receptors is restricted to the mesolimbic pathway, which is often called the “reward pathway.” This pathway is associated with emotions, motivation, and behavior. There is evidence that these receptors are upregulated in response to the repeated use of psychostimulants, such as cocaine, making these receptors a potential target for pharmaceutical therapeutics for drug addiction. In the present study, ...

Contributors
Mendoza, Rachel Ann, Neisewander, Janet, Olive, Foster, et al.
Created Date
2017-05

Abstract: The RAS/RAF/MEK/ERK (RAS signaling cascade) pathway is a highly conserved biochemical signaling cascade that exists in every mammalian cell. The pathway is highly versatile in functionality due to hundreds of substrates that regulate metabolism, apoptosis, and proliferation in both adult and developing tissues. The RAS signaling cascade has been examined in the context of cancers since mutations can lead to the disruption of the cell cycle and unregulated cellular proliferation. In addition, germline mutations in the pathway have been shown to cause a group of syndromes known as RASopathies. RASopathies are marked by facial defects, seizures, developmental delays, and ...

Contributors
Gonzalez, Javier, Newbern, Jason, Neisewander, Janet, et al.
Created Date
2016-05

Within the field of psychopharmacology, there has been difficultly with studying the functional effects of dopamine at the D2 receptor apart from other dopamine receptors due to the lack of drugs that are selective for the D2 receptor. The purpose of this study was to observe the motivational and locomotor effects of using three varying doses (1.0, 3.0, and 5.6 mg/kg) of a new, highly selective D2 antagonist, SV293. These doses were tested across five different conditions that explore the effects of controls, SV293 by itself, and in combination with cocaine. These tests are designed to separately assess the effects ...

Contributors
Lynn, Jeffrey Spencer, Neisewander, Janet, Orchinik, Miles, et al.
Created Date
2014-05

Substance abuse disorder is a debilitating condition characterized by recurring drug-seeking behaviors and high rates of relapse. In male rats, this tendency to engage in drug-seeking behavior can be inhibited by environmental enrichment (EE) during abstinence. We have shown previously that cocaine-seeking behavior is associated with an increase in addiction-related genes such as Arc and CamkIIa and a decrease in the microRNA miR-495. We have also shown that miR-495 inhibits expression of Arc and CamkIIa post-transcriptionally. Therefore, we hypothesize that reduced cocaine-seeking behavior in EE female rats is associated with a downregulation of these addiction-related genes as well as an ...

Contributors
St Peter, Madeleine Kay, Neisewander, Janet, Newbern, Jason, et al.
Created Date
2017-05

MicroRNAs are small, non-coding transcripts that control gene expression by preventing mRNA from translating into proteins. They have been implicated to play a role in many drug addictions. We previously found that miR-495 targets several addiction-related genes (ARGs) and is highly expressed in the nucleus accumbens (NAc). We also found miR-495 is downregulated in the NAc following acute cocaine administration, and cocaine motivation measured by breakpoint on a progressive ratio schedule of cocaine reinforcement is decreased when miR-495 is overexpressed. In this study, we manipulated the endogenous levels of miR-495 by using a viral vector. Using an animal model, rats ...

Contributors
Chaudhury, Trisha, Neisewander, Janet, Newbern, Jason, et al.
Created Date
2017-05

Previous findings from our lab have demonstrated that nicotine and social reward have synergistic effects when experienced together versus when experienced separately. The purpose of this experiment is to understand the neural mechanisms underlying this synergistic effect by quantifying Fos protein, a marker for neural activation, in various brain regions. We utilized the conditioning place preference (CPP) model to assess reward. Four groups of adolescent male rats (n=120) were given either nicotine (Nic) (0.1 mg/kg/mL) or saline (Sal) and were placed in the CPP apparatus either with a social partner (Soc) or alone (Iso). Thus, groups were: 1.)Sal+Iso, 2).Sal+Soc, 3).Nic+Iso, ...

Contributors
Goenaga, Julianna Gloria, Neisewander, Janet, Orchinik, Miles, et al.
Created Date
2013-05

Substance abuse disorders affect 15.3 million people worldwide. The field has primarily focused on dopaminergic drugs as treatments for substance use disorders. However, recent work has demonstrated the potential of serotonergic compounds to treat substance abuse. Specifically, the serotonin 1B receptor (5-HT1BR), a Gi-coupled receptor located throughout the mesocorticolimbic dopamine system, has been implicated in the incentive motivational and rewarding effects of cocaine. Our research suggests that the stimulation of 5-HT1BRs produces different effects at various time points in the addiction cycle. During maintenance of chronic cocaine administration, 5-HT1BR stimulation has a facilitative effect on the reinforcing properties of cocaine. ...

Contributors
Brunwasser, Samuel Joshua, Neisewander, Janet, Pentkowski, Nathan, et al.
Created Date
2014-05