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Barrett, The Honors College Thesis/Creative Project Collection


Barrett, the Honors College accepts high performing, academically engaged students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project, supervised and defended in front of a faculty committee. The thesis or creative project allows students to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is a student’s opportunity to explore areas of academic interest with greater intensity than is possible in a single course. It is also an opportunity to engage with professors, nationally recognized in their fields and specifically interested and committed to working with honors students. This work provides tangible evidence of a student’s research, writing and creative skills to graduate schools and/or prospective employers.


Contributor
Date Range
2013 2018


Partial differential equation (PDE) models are widely used for modeling processes in the physical sciences, economics, and sociology, but are otherwise new to the realm of social media. They allow researchers to construct a single spatiotemporal mathematical model to predict, in the case of this study, the level of information saturation at particular points in space at specific times. Utilizing data from the popular social network Twitter, this study presents a preliminary work looking into the effects of aggregating spatial data on such a PDE model. In other literature, the source of analytical and statistical bias that results from arbitrary ...

Contributors
Raymond, Ross Edward Scott, Kwon, Kyounghee Hazel, Gruber, Diane, et al.
Created Date
2016-05

Stress, empathy, and emotion regulation are factors that can greatly shape an individual’s behavior, thoughts, and physiology. The degree to which an individual experiences stress, demonstrates empathy, or is able to regulate emotions can influence his or her ability to establish strong social bonds. The current study investigated the relationships among stress, empathy, and emotion regulation and considered gender differences in these relationships. I hypothesized that higher levels of current stress would be associated with lower levels of empathy and greater difficulties with emotion regulation, and that empathy and emotion regulation would be positively related. Supporting these hypotheses, the following ...

Contributors
Hanna, Rand Maria, Roberts, Nicole, Burleson, Mary, et al.
Created Date
2016-12

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for ...

Contributors
Seto, David Hua, Marshall, Pamela, Wagner, Carl, et al.
Created Date
2015-05

Ancestry estimation in forensic anthropology has been one of the most complex determinations to make from the human skeleton. There is a long history in biological anthropology using different morphological characteristics from the skull and other areas of the skeleton but it remains a difficult estimation that always has some variability. Currently, more studies have been conducted in morphological and metric methods from the skull of ancestry estimation to better the accuracy of the determination. Since most forensic cases are not in the best condition, there also must be other estimation methods from other bones from the remains such as ...

Contributors
Dowell, Kori Kalei, Falsetti, Anthony, Kanthaswamy, Sreetharan, et al.
Created Date
2016-12

Pharmacokinetics describes the movement and processing of a drug in a body, while Pharmacodynamics describes the drug's effect on a given subject. Pharmacokinetic/Pharmacodynamic(Pk/Pd) models have become a fundamental tool when predicting bacterial behavior and drug development. In November of 2009, Katsube et al. published their paper detailing their Pk/Pd model for the drug Doripenem and the bacteria P. aeruginosa. In their paper, they determined that there is a dependent relationship between the drug's effectiveness and the dosing strategy of the drug. Therefore, this thesis has applied optimal control in order to optimize the drug's effectiveness, while not burdening the subject ...

Contributors
Sawkins, Bryan Thomas, Camacho, Erika, Wirkus, Stephen, et al.
Created Date
2018-05

Bloodstain pattern analysis can provide telling evidence from a crime scene based on the clues left in the blood, but the field itself is highly problematic since the evidence extracted is dependent upon the interpretation of the analyst. Although some aspects of this type of analysis have been scientifically supported, most are not seen as positively accurate. Since certainty is the basis for acceptance of courtroom testimony, it is important that these unsettled aspects become more understood. This experiment examines the diameter of a weapon and how it affects its cast-off pattern. Weapons with four different diameters were used to ...

Contributors
Betz, Alexandra Marie, Kobojek, Kimberly, Jacobson, David, et al.
Created Date
2016-05

As human beings we go through the world interpreting – seeing a situation, gathering context, and making a decision on the meaning of the thing we just experienced. The philosopher Martin Heidegger calls this way of being hermeneutics – a practice of interpretation. This method of approach does not ignore a person’s bias, instead bias is highlighted, understood, and possibly even overcome. In the following pages the basic definition and process of hermeneutics will be discussed. Leading into the difference between calculative and meditative thought – scientific and philosophical – in order to later discuss the possibility and need to ...

Contributors
Craig, Catherine Anne, Kobojek, Kimberly, Watrous, Lisa, et al.
Created Date
2018-05

Child abuse is a hard topic to talk about, and even harder to diagnose without proper training. Though there is a list of general characteristics that child abuse victim’s exhibit, it could be difficult to diagnose because everyone reacts to maltreatment differently. Teachers are required by law to report any case where they believe a child is in an abusive environment. Unfortunately, teachers are given the tools to report the abuse, but they lack the knowledge of what to look for. The results are two fold; one is there is an overflow of false reporting, and two, the children who ...

Contributors
Baker, Karen Colette, Kobojek, Kimberly, Broberg, Gregory, et al.
Created Date
2015-12

As threats to Earth's biodiversity continue to evolve, an effective methodology to predict such threats is crucial to ensure the survival of living species. Organizations like the International Union for Conservation of Nature (IUCN) monitor the Earth's environmental networks to preserve the sanctity of terrestrial and marine life. The IUCN Red List of Threatened Species informs the conservation activities of governments as a world standard of species' risks of extinction. However, the IUCN's current methodology is, in some ways, inefficient given the immense volume of Earth's species and the laboriousness of its species' risk classification process. IUCN assessors can take ...

Contributors
Woodyard, Megan, Broatch, Jennifer, Polidoro, Beth, et al.
Created Date
2018-05

The FDA-approved drug bexarotene has been predominantly utilized for the treatment of cutaneous T-cell lymphoma (CTLC), but has shown promise as an off label treatment for various other cancers as well as Alzheimer’s disease (AD). However, harmful side effects such as hypothyroidism have catalyzed a search for alternative rexinoids which retain similar levels of RXR agonism while reducing the undesirable effects incurred by bexarotene. This honors thesis outlines the steps taken to design and synthesize novel analogues of the selective retinoid-X-receptor (RXR) agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). Corresponding NMR spectra indicates the successful construction of four novel compounds which are structurally ...

Contributors
Davidson, Jesse Raymond, Wagner, Carl, Ball, Rebecca, et al.
Created Date
2016-05