Barrett, The Honors College Thesis/Creative Project Collection

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Date Range
2015 2017

Substance abuse disorder is a debilitating condition characterized by recurring drug-seeking behaviors and high rates of relapse. In male rats, this tendency to engage in drug-seeking behavior can be inhibited by environmental enrichment (EE) during abstinence. We have shown previously that cocaine-seeking behavior is associated with an increase in addiction-related genes such as Arc and CamkIIa and a decrease in the microRNA miR-495. We have also shown that miR-495 inhibits expression of Arc and CamkIIa post-transcriptionally. Therefore, we hypothesize that reduced cocaine-seeking behavior in EE female rats is associated with a downregulation of these addiction-related genes as well as an ...

Contributors
St Peter, Madeleine Kay, Neisewander, Janet, Newbern, Jason, et al.
Created Date
2017-05

The work for this thesis was done in conjunction to that of my capstone project, which focused on understanding the effects of powder re-use on products built via Direct Metal Laser Sintering (DMLS), a specific additive manufacturing (AM) technique where powder particles are sintered together to form final parts. Honeywell Aerospace helped support this research by providing materials and mentorship; this work will play a key role in their decision to implement DMLS and other AM methods on a larger scale. Whereas the capstone focuses on the technical details of constructing characterization equipment, analyzing data, and formulating a concluding recommendation ...

Contributors
Murella, Anoosha Sainagaki, Adams, James, Tasooji, Amaneh, et al.
Created Date
2016-05

The multibillion dollar fantasy sports industry is comprised of two main groups: traditional fantasy sports (TFS) and daily fantasy sports (DFS). TFS users play in season­long leagues while DFS users play in one­day contests. In November 2015, New York Attorney General Eric T. Schneiderman opened an investigation into the DFS businesses FanDuel and DraftKings following allegations of “insider trading” by employees who may have had access to information that was not available to the public. Schneiderman’s investigation generated questions about DFS and how they differed from TFS. It was also the first instance of the differentiation between the two. This ...

Contributors
Landauer, Kevin James, Ingram-Waters, Mary, Fette, Donald, et al.
Created Date
2016-05

Acyl Carrier Protein (ACP) is a small, acidic protein that plays an essential role in fatty acid synthesis by elongating fatty acid chains. ACP was isolated from an extract of a modified strain of Synechocystis sp. PCC 6803 that contains a thioesterase and from which the acyl-ACP synthetase has been deleted. Using ammonium sulfate precipitation to isolate a crude protein fraction containing ACP, immunoblot analysis was performed to determine relative amounts of free and acylated-ACP in the cell. The nature of fatty acids attached to ACP was determined by creating butylamide derivatives that were analyzed using GC/MS. Immunoblot analysis showed ...

Contributors
Wu, Sharon Gao, Vermaas, Willem, Redding, Kevin, et al.
Created Date
2016-05

Full thickness wounds encompass damage through the epidermis and dermis with characteristic loss of structure and healing through secondary intention. Two treatments that have been thoroughly researched and shown efficacy in treating these types of wounds are platelet-rich-gels (PRG) and electro-spun collagen scaffolds. However, little research has been done to investigate the two as a combination treatment, a biomaterial enrich platelet-rich-gel. PRGs provide the wound with growth factors and cytokines that are naturally present in a wound bed, but in a concentration above that of native physiological conditions. The electro-spun collagen scaffold works on two premises, the first is that ...

Contributors
Robinson, Andrew Joseph, Massia, Stephen, Tabor, Aaron, et al.
Created Date
2015-12

Proper developmental fidelity ensures uninterrupted progression towards sexual maturity and species longevity. However, early development, the time-frame spanning infancy through adolescence, is a fragile state since organisms have limited mobility and responsiveness towards their environment. Previous studies have shown that damage during development leads to an onset of developmental delay which is proportional to the extent of damage accrued by the organism. In contrast, damage sustained in older organisms does not delay development in response to tissue damage. In the fruit fly, Drosophila melanogaster, damage to wing precursor tissues is associated with developmental retardation if damage is sustained in young ...

Contributors
Contreras Rodriguez, Jesus, Lupone, Teresa, Beckett, Chaz, et al.
Created Date
2016-05

The main objective of this project is to create a hydrogel based material system to capture and release CCRF-CEM Leukemia cancer cells via chemo-mechanical modulation. This system is composed of an aptamer-functionalized hydrogel thin film at the bottom of a microfluidic channel, which changes its film thickness as the temperature of the fluid in the system changes. The functionalized hydrogel film has been created as the primary steps to creating the microfluidic device that could capture and release leukemia cells by turning the temperature of the fluid and length of exposure. Circulating tumor cells have recently become a highly studied ...

Contributors
Paxton, Rebecca Joanne, Stephanopoulos, Nicholas, He, Ximin, et al.
Created Date
2016-12

The college textbook is the most commonly required component of almost any college course, regardless of a student’s academic discipline. Professors often expect students to have access to the textbook and to use it to complete assigned readings. Textbooks often contain features that are designed to facilitate active reading, or critical engagement with the information being read, to enhance learning of the material. However, students often do not read or prioritize reading the textbook. Students who do read, tend not to read the textbook as intended or use many of the features designed to promote active reading and enhanced learning ...

Contributors
Rudolph, Alexia Marion, Vanmali, Binaben, Chen, Ying-Chih, et al.
Created Date
2016-05

Genetically encoded non-canonical amino acids (NCAAs) have allowed researchers to access functionalities that would be otherwise unavailable with the naturally-occurring amino acids. The metal-chelating NCAA (2,2'-bipyridin-5yl)alanine (Bpy-ala) has recently been employed, in tandem with computational modeling, to drive the assembly of a homotrimeric protein complex in the presence of a metal ion, specifically Fe(II). While a successful design was identified to form a homotrimeric complex with an iron-trisbipyridyl [Fe(Bpy-ala)3]2+ core when expressed in E. coli, its subsequent utility was marred by an excessively strong protein-protein interaction thus leading to a lack of metal-dependency. This thesis describes principles of protein design ...

Contributors
Almhjell, Patrick James, Mills, Jeremy H., Moore, Gary F., et al.
Created Date
2017-05

My grandmother, Mickey Gilbert, is the daughter of Italian immigrants, Clemente Saulino and Anna Moccia, who married in Italy and moved to a small mining town called Lynch, Kentucky in 1928, the year before my grandmother was born. Her family moved to an apartment in Cumberland, Kentucky where Clemente started a dry-cleaning business. Grandma's sister, Berenice, was born in 1931 and then her mother had a child every five years for 15 years, adding Joanne, Joe, and Tom to the family. Her family was religious and attended church every Sunday and holy day. Grandma went to a Catholic boarding school ...

Contributors
Workman, Anna Michela, DeLuse, Stephanie, Boyd, Patricia, et al.
Created Date
2016-12

Barrett, the Honors College accepts high performing, academically engaged students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project, supervised and defended in front of a faculty committee. The thesis or creative project allows students to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is a student’s opportunity to explore areas of academic interest with greater intensity than is possible in a single course. It is also an opportunity to engage with professors, nationally recognized in their fields and specifically interested and committed to working with honors students. This work provides tangible evidence of a student’s research, writing and creative skills to graduate schools and/or prospective employers.