Barrett, The Honors College Thesis/Creative Project Collection

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2000 2018

With the rising data output and falling costs of Next Generation Sequencing technologies, research into data compression is crucial to maintaining storage efficiency and costs. High throughput sequencers such as the HiSeqX Ten can produce up to 1.8 terabases of data per run, and such large storage demands are even more important to consider for institutions that rely on their own servers rather than large data centers (cloud storage)1. Compression algorithms aim to reduce the amount of space taken up by large genomic datasets by encoding the most frequently occurring symbols with the shortest bit codewords and by changing the ...

Contributors
Howell, Abigail, Cartwright, Reed, Wilson Sayres, Melissa, et al.
Created Date
2018-04-14

Nicotine addiction remains a prevalent public health issue, and the FDA has released a statement outlining the systematic reduction of nicotine to non-zero levels in the coming years. Current research has not yet established the effects of abrupt nicotine dose reduction on vulnerability to relapse, nor has abrupt nicotine dose reduction been evaluated in terms of behavioral economic characteristics of demand and elasticity been evaluated for reduced doses of nicotine. Using a rat model, we first evaluated the comparability of between- and within-session protocols for establishing characteristics of demand and elasticity for nicotine to shorten experimental timelines for this study ...

Contributors
Cabrera-Brown, Gabriella, Gipson-Reichardt, Cassandra, Olive, M. Foster, et al.
Created Date
2017-12-08

Exosomes have been known to secrete an increased amount of miRNA and noncoding genes that are abnormally expressed in various cancer subtypes. Thus, they may be an early marker for pediatric cancer types that are more difficult to diagnosis without invasive techniques, and may also help identify progression of the disease. In the project, six types of pediatric cancer cell lines, along with their extracted exosomes, were analyzed and tested for different monoclonal antibodies through western blot analysis. The genes EWS-FLI1 and FGFR4 were also identified in some cancer cell lines through Reverse-Transcriptase Polymerase Chain Reaction analysis (RT-PCR). The results ...

Contributors
Kaur Bhinder, Harsimran, Lake, Douglas, Azorsa, David
Created Date
2017-11-30

This thesis seeks to evaluate whether the benefits of spinal fusion surgeries are worth their increasing costs. The paper examines the trends that contribute to these surgeries’ increasing prices and then evaluates the customer impact of these surgeries in order to make a conclusion on whether the surgeries are worth it. This paper discusses the main factors that contribute to the increase in prices of these surgeries and these include the aging population, the increase in diabetes rates, and the practice of purchasing physicians owned distributorships (PODs) devices in some hospitals. The paper concluded that there is a definite correlation ...

Contributors
Disengi Nkunzi, Jossel, Allenby, Braden, Bohl, Michael
Created Date
2017-11-20

Since the emergence of behavioral economics, our understanding of human behavior and decision-making has improved through the widespread use of conducting experiments. In tandem, behavioral and experimental economists seek to merge psychology and emotion into economic thought to better understand the agents that comprise our economic systems. Vernon Smith, a Nobel Prize winning experimental economist, wrote an article on how economic agents in asset market experiments create bubbles (commonly referred to as “booms and busts” or “market crashes”). This study builds on Smith’s work and seeks to better understand how participants behave when given information about the expected outcome of ...

Contributors
Labansat, Derek, Goegan, Brian, Eaton, John
Created Date
2017-11-01

Many students are eager to take on internships in the hopes of learning what a full-time may entail. Yet, a disconnect seems to exist between student’s perceptions and employer’s expectations in regard to what an internship entails. Many students are unsure of what the requirements are required obtain an internship just as employers are unaware of what students are seeking in an internship experience. The ultimate goal for every new collegiate student should be to have a job lined up for them upon graduation. However, as most students already know, entry-level jobs require experience. From start to finish, the process ...

Contributors
Simpson, Max, Eaton, John, Kutz, Elana
Created Date
2017-10-27

Across​ ​group​ ​studies,​ ​identifying​ ​as​ ​part​ ​of​ ​one​ ​group​ ​over​ ​the​ ​other​ ​is​ ​instrumental​ ​in determining​ ​the​ ​traits​ ​of​ ​an​ ​individual’s​ ​personality.​ ​Furthermore,​ ​when​ ​someone’s​ ​style​ ​of​ ​dress causes​ ​them​ ​to​ ​fit​ ​into​ ​a​ ​group,​ ​their​ ​personality​ ​is​ ​likely​ ​to​ ​be​ ​dictated​ ​by​ ​what​ ​they​ ​are​ ​wearing and​ ​who​ ​they​ ​are​ ​with.​ ​Attendees​ ​of​ ​comic​ ​conventions​ ​have​ ​been​ ​part​ ​of​ ​a​ ​growing​ ​trend​ ​to dress​ ​up​ ​as​ ​their​ ​favorite​ ​characters​ ​from​ ​different​ ​anime,​ ​manga,​ ​television​ ​shows,​ ​books,​ ​video games,​ ​etc.,​ ​where​ ​they​ ​can​ ​meet​ ​like-minded​ ​people​ ​who​ ​share​ ​similar​ ​interests​ ​and​ ​hobbies. When​ ​combining​ ​changes​ ​of​ ​affect,​ ​and​ ​similarities​ ​of​ ...

Contributors
Leshner, Connor, De La Garza, Amira, Mack, Robert, et al.
Created Date
2017-10

In responding to any human rights violation, two questions often arise: what can be done, and who should do it? In response to the horrible violation that is sex trafficking in Russia and Ukraine, this paper will explore the historical, social, political, and economic context that facilitates trafficking, identify common understandings of the issue and corresponding approaches, and attempt to synthesize an approach to combatting sex trafficking that will be most effective in Russia and Ukraine. I will argue that an effective anti-trafficking strategy requires four axes of approach, and that current efforts in Russia and Ukraine are currently insufficient ...

Contributors
Jay, Emily, Stoff, Laurie, Von Hagen, Mark, et al.
Created Date
2017-08-18

Engaging the immune system to attack neoplastic glial cells in the brain may be a promising approach to eliminate glioblastoma (GBM), a deadly form of primary brain cancer with low median survival. A bispecific fusion protein, anti-CD3/chlorotoxin (ACDClx), has been developed to engage cytotoxic T cells for destruction against GBM with little to no expected toxicity to surrounding healthy tissue. Previously, ACDClx has been demonstrated to induce calcium flux in T cells, indicating activation when cultured with GBM cells in vitro. Here, ACDClx fails to demonstrate successful binding to the CD3 domain of the T-cell receptor on CD4 T cells ...

Contributors
Bichler, Sierra Ariel, Blattman, Joseph, Mor, Tsafrir, et al.
Created Date
2017-08-08

Gait training therapies are methods for improving the walking stability of individuals who have difficulty walking, whether it is due to injury or neuromuscular conditions. Perturbation training that causes individuals to correct their balance and actively improve their stability could potentially lead to longer term benefits for those with unstable gait. Subjects had the medial lateral movement of their center of mass measured through motion-tracking software (D-Flow 3 and Vicon Nexus 2.2). Perturbation training completed with the GRAIL treadmill randomly triggered medial-lateral sway perturbations of 3 cm a total of fifteen times throughout a five minute training period. Data collected ...

Contributors
Jamali, Neema, Lockhart, Thurmon, Soangra, Rahul, et al.
Created Date
2017-07-24

Barrett, the Honors College accepts high performing, academically engaged students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project, supervised and defended in front of a faculty committee. The thesis or creative project allows students to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is a student’s opportunity to explore areas of academic interest with greater intensity than is possible in a single course. It is also an opportunity to engage with professors, nationally recognized in their fields and specifically interested and committed to working with honors students. This work provides tangible evidence of a student’s research, writing and creative skills to graduate schools and/or prospective employers.