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ASU Scholarship Showcase


This growing collection consists of scholarly works authored by ASU-affiliated faculty, students and community members, and contains many open access articles. ASU-affiliated authors are encouraged to Share Your Work in the ASU Digital Repository.




MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-transcriptional level by targeting degenerate elements primarily in 3′untranslated regions (3′UTRs) of mRNAs. Individual miRNAs can regulate networks of hundreds of genes, yet for the majority of miRNAs few, if any, targets are known. Misexpression of miRNAs is also a major contributor to cancer progression, thus there is a critical need to validate miRNA targets in high-throughput to understand miRNAs' contribution to tumorigenesis. Here we introduce a novel high-throughput assay to detect miRNA targets in 3′UTRs, called Luminescent Identification of Functional Elements in 3′UTRs (3′LIFE). We demonstrate the …

Contributors
Wolter, Justin, Kotagama, Kasuen, Pierre-Bez, Alexandra C., et al.
Created Date
2014-09-29

mRNA expression dynamics promote and maintain the identity of somatic tissues in living organisms; however, their impact in post-transcriptional gene regulation in these processes is not fully understood. Here, we applied the PAT-Seq approach to systematically isolate, sequence, and map tissue-specific mRNA from five highly studied Caenorhabditis elegans somatic tissues: GABAergic and NMDA neurons, arcade and intestinal valve cells, seam cells, and hypodermal tissues, and studied their mRNA expression dynamics. The integration of these datasets with previously profiled transcriptomes of intestine, pharynx, and body muscle tissues, precisely assigns tissue-specific expression dynamics for 60% of all annotated C. elegans protein-coding genes, …

Contributors
Blazie, Stephen, Geissel, Heather, Wilky, Henry, et al.
Created Date
2017-03-27

Foodways have been a component of archaeological research for decades. However, cooking and food preparation, as specific acts that could reveal social information about life beyond the kitchen, only became a focus of archaeological inquiry more recently. A review of the literature on cooking and food preparation reveals a shift from previous studies on subsistence strategies, consumption, and feasting. The new research is different because of the social questions that are asked, the change in focus to preparation and production rather than consumption, and the interest in highlighting marginalized people and their daily experiences. The theoretical perspectives the literature addresses …

Contributors
Graff, Sarah, Barrett, the Honors College
Created Date
2017-10-04

MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA family members possess. Here, we study evolutionary patterns of metazoan miRNAs, focusing on the targeting preferences of the let-7 and miR-10 families. These studies reveal hotspots for sequence evolution with implications for targeting and secondary structure. High-throughput screening for functional targets reveals that each miRNA represses sites with distinct features and regulates a large number of …

Contributors
Wolter, Justin, Le, Hoai Huang Thi, Linse, Alexander, et al.
Created Date
2016-12-07

Background While prior studies have quantified the mortality burden of the 1957 H2N2 influenza pandemic at broad geographic regions in the United States, little is known about the pandemic impact at a local level. Here we focus on analyzing the transmissibility and mortality burden of this pandemic in Arizona, a setting where the dry climate was promoted as reducing respiratory illness transmission yet tuberculosis prevalence was high. Methods Using archival death certificates from 1954 to 1961, we quantified the age-specific seasonal patterns, excess-mortality rates, and transmissibility patterns of the 1957 H2N2 pandemic in Maricopa County, Arizona. By applying cyclical Serfling …

Contributors
Cobos, April, Nelson, Clinton, Jehn, Megan, et al.
Created Date
2016-08-11

Transdisciplinary research practice has become a core element of global sustainability science. Transdisciplinary research brings with it an expectation that people with different backgrounds and interests will learn together through collective problem solving and innovation. Here we introduce the concept of “transdisciplinary communities of practice, ” and draw on both situated learning theory and transdisciplinary practice to identify three key lessons for people working in, managing, or funding such groups. (1) Opportunities need to be purposefully created for outsiders to observe activities in the core group. (2) Communities of practice cannot be artificially created, but they can be nurtured. (3) …

Contributors
Cundill, Georgina, Roux, Dirk J., Parker, John, et al.
Created Date
2014-11-30

In Ritual and Religion in the Making of Humanity, Roy Rappaport misses an opportunity to more tightly theorize the synergistic relationship between concepts of the divine, the psyches of ritual participants, and the adaptive dynamics of religious sociality. This paper proposes such a theory by drawing on implicit features of Rappaport’s account, fulfilling his goal of a “cybernetics of the holy.” I argue that concepts of the divine, when made authoritative for participants through ritual, have three important effects: they invite intense and meaningful reconstructions of personal identity according to paradigmatic examples; they act as a form of encoded social …

Contributors
Cassell, Paul, Barrett, the Honors College
Created Date
2013-11-30

Rice is an essential crop in Ghana. Several aspects of rice have been studied to increase its production; however, the environmental aspects, including impact on climate change, have not been studied well. There is therefore a gap in knowledge, and hence the need for continuous research. By accessing academic portals, such as Springer Open, InTech Open, Elsevier, and the Kwame Nkrumah University of Science and Technology’s offline campus library, 61 academic publications including peer reviewed journals, books, working papers, reports, etc. were critically reviewed. It was found that there is a lack of data on how paddy rice production systems …

Contributors
Boateng, Kofi K., Obeng, George Yaw, Mensah, Ebenezer, et al.
Created Date
2017-01-20

Scholarly communication is at an unprecedented turning point created in part by the increasing saliency of data stewardship and data sharing. Formal data management plans represent a new emphasis in research, enabling access to data at higher volumes and more quickly, and the potential for replication and augmentation of existing research. Data sharing has recently transformed the practice, scope, content, and applicability of research in several disciplines, in particular in relation to spatially specific data. This lends exciting potentiality, but the most effective ways in which to implement such changes, particularly for disciplines involving human subjects and other sensitive information, …

Contributors
Hartter, Joel, Ryan, Sadie J., MacKenzie, Catrina A., et al.
Created Date
2013-09-13

Background Blindness has evolved repeatedly in cave-dwelling organisms, and many hypotheses have been proposed to explain this observation, including both accumulation of neutral loss-of-function mutations and adaptation to darkness. Investigating the loss of sight in cave dwellers presents an opportunity to understand the operation of fundamental evolutionary processes, including drift, selection, mutation, and migration. Results Here we model the evolution of blindness in caves. This model captures the interaction of three forces: (1) selection favoring alleles causing blindness, (2) immigration of sightedness alleles from a surface population, and (3) mutations creating blindness alleles. We investigated the dynamics of this model …

Contributors
Cartwright, Reed, Schwartz, Rachel, Merry, Alexandra, et al.
Created Date
2017-02-07