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ASU Scholarship Showcase


This growing collection consists of scholarly works authored by ASU-affiliated faculty, students and community members, and contains many open access articles. ASU-affiliated authors are encouraged to Share Your Work in the ASU Digital Repository.


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Date Range
2010 2018


Remote sensors like Doppler lidars can map the winds with high accuracy and spatial resolution. One shortcoming of lidars is that the radial velocity measured by the lidar does not give a complete picture of the windfield necessitating additional data processing to reconstruct the windfield. Most of the popular vector retrieval algorithms rely on the homogenous wind field assumption which plays a vital role in reducing the indeterminacy of the inverse problem of obtaining Cartesian velocity from radial velocity measurements. Consequently, these methods fail in situations where the flow is heterogeneous e.g., Turbine wakes. Alternate methods are based either on …

Contributors
Cherukuru, Nihanth, Calhoun, Ronald, Krishnamurthy, Raghavendra, et al.
Created Date
2017-10

Presented in this paper is a bi-directional out-of-plane actuator which combines the merits of the electrostatic repulsive principle and the electrostatic attractive principle. By taking advantage of the electrostatic repulsive mode, the common “pull-in” instability can be lessened to enlarge the displacement, and by applying the electrostatic attractive mode, the out-of-plane displacement is further enlarged. The implications of changing the actuator’s physical dimensions are discussed, along with the two-layer polysilicon surface microfabrication process used to fabricate such an actuator. The static characteristics of the out-of-plane displacement versus the voltage of both modes are tested, and displacements of 1.4 μm and …

Contributors
Ren, Hao, Wang, Weimin, Tao, Fenggang, et al.
Created Date
2013-12-05

Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a comprehensive understanding of cancer dormancy and the “switch” from a dormant to a proliferative state still needs to be strengthened from both a basic and clinical point of view. Computational modeling enables one to explore a variety of scenarios for possible but realistic microscopic dormancy mechanisms and their predicted outcomes. The aim of this paper is to devise such a predictive computational model of dormancy with an …

Contributors
Chen, Duyu, Jiao, Yang, Torquato, Salvatore, et al.
Created Date
2014-10-16

Due to the limitation of current pharmacological therapeutic strategies, stem cell therapies have emerged as a viable option for treating many incurable neurological disorders. Specifically, human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs), a multipotent cell population that is capable of near indefinite expansion and subsequent differentiation into the various cell types that comprise the central nervous system (CNS), could provide an unlimited source of cells for such cell-based therapies. However the clinical application of these cells will require (i) defined, xeno-free conditions for their expansion and neuronal differentiation and (ii) scalable culture systems that enable their expansion and …

Contributors
Tsai, Yihuan, Cutts, Joshua, Kimura, Azuma, et al.
Created Date
2015-05-13

Synchronization of neuronal activity is associated with neurological disorders such as epilepsy. This process of neuronal synchronization is not fully understood. To further our understanding, we have experimentally studied the progression of this synchronization from normal neuronal firing to full synchronization. We implemented nine FitzHugh-Nagumo neurons (a simplified Hodgkin-Huxley model) via discrete electronics. For different coupling parameters (synaptic strengths), the neurons in the ring were either unsynchronized or completely synchronized when locally coupled in a ring. When a single long-range connection (nonlocal coupling) was introduced, an intermediate state known as a chimera appeared. The results indicate that (1) epilepsy is …

Contributors
Arumugam, Easwara Moorthy Essaki, Spano, Mark, Ira A. Fulton Schools of Engineering, et al.
Created Date
2015-01-01

Potential climate change impacts on summer precipitation and subsequent hydrologic responses in the southwestern U.S. are poorly constrained at present due to a lack of studies accounting for high resolution processes. In this investigation, we apply a distributed hydrologic model to the Beaver Creek watershed of central Arizona to explore its utility for climate change assessments. Manual model calibration and model validation were performed using radar-based precipitation data during three summers and compared to two alternative meteorological products to illustrate the sensitivity of the streamflow response. Using the calibrated and validated model, we investigated the watershed response during historical (1990–2000) …

Contributors
Hawkins, Gretchen, Vivoni, Enrique, Robles-Morua, Agustin, et al.
Created Date
2015-07-01

The term adaptive intervention has been used in behavioral medicine to describe operationalized and individually tailored strategies for prevention and treatment of chronic, relapsing disorders. Control systems engineering offers an attractive means for designing and implementing adaptive behavioral interventions that feature intensive measurement and frequent decision-making over time. This is illustrated in this paper for the case of a low-dose naltrexone treatment intervention for fibromyalgia. System identification methods from engineering are used to estimate dynamical models from daily diary reports completed by participants. These dynamical models then form part of a model predictive control algorithm which systematically decides on treatment …

Contributors
Deshpande, Sunil, Rivera, Daniel, Younger, Jarred W., et al.
Created Date
2014-09-01

Background Heterogeneity within cell populations is relevant to the onset and progression of disease, as well as development and maintenance of homeostasis. Analysis and understanding of the roles of heterogeneity in biological systems require methods and technologies that are capable of single cell resolution. Single cell gene expression analysis by RT-qPCR is an established technique for identifying transcriptomic heterogeneity in cellular populations, but it generally requires specialized equipment or tedious manipulations for cell isolation. Results We describe the optimization of a simple, inexpensive and rapid pipeline which includes isolation and culture of live single cells as well as fluorescence microscopy …

Contributors
Yaron, Jordan, Ziegler, Colleen, Tran, Thai, et al.
Created Date
2014-05-08

Transmission systems are under stress and need to be upgraded. Better utilization of the existing grid provides a fast and cheap alternative to building new transmission. One way to improve the utilization of the transmission network is power flow control via flexible AC transmission system (FACTS) devices. While FACTS devices are used today, the utilization of these devices is limited; traditional dispatch models (e.g., security con-strained economic dispatch) assume a fixed, static transmission grid even though it is rather flexible. The primary barrier is the complexity that is added to the power flow problem. The mathe-matical representation of the DC …

Contributors
Sahraei-Ardakani, Mostafa, Hedman, Kory, Ira A. Fulton Schools of Engineering, et al.
Created Date
2015-07

Decoding motor intent from recorded neural signals is essential for the development of effective neural-controlled prostheses. To facilitate the development of online decoding algorithms we have developed a software platform to simulate neural motor signals recorded with peripheral nerve electrodes, such as longitudinal intrafascicular electrodes (LIFEs). The simulator uses stored motor intent signals to drive a pool of simulated motoneurons with various spike shapes, recruitment characteristics, and firing frequencies. Each electrode records a weighted sum of a subset of simulated motoneuron activity patterns. As designed, the simulator facilitates development of a suite of test scenarios that would not be possible …

Contributors
Abdelghani, Mohamed N., Abbas, James, Horch, Kenneth W., et al.
Created Date
2014-11-14