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Series
  • GENOME BIOLOGY
Date Range
2015 2017

Whole-genome analyses of human medulloblastomas show that the dominant clone at relapse is present as a rare subclone at primary diagnosis.

Contributors
Chowell, Diego, Boddy, Amy, Mallo Adan, Diego, et al.
Created Date
2016-02-24

It remains challenging to predict regulatory variants in particular tissues or cell types due to highly context-specific gene regulation. By connecting large-scale epigenomic profiles to expression quantitative trait loci (eQTLs) in a wide range of human tissues/cell types, we identify critical chromatin features that predict variant regulatory potential. We present cepip, a joint likelihood framework, for estimating a variant’s regulatory probability in a context-dependent manner. Our method exhibits significant GWAS signal enrichment and is superior to existing cell type-specific methods. Furthermore, using phenotypically relevant epigenomes to weight the GWAS single-nucleotide polymorphisms, we improve the statistical power of the gene-based association ...

Contributors
Li, Mulin Jun, Li, Miaoxin, Liu, Zipeng, et al.
Created Date
2017-03-16

A new study on sex chromosome evolution in papaya helps to illuminate sex chromosome biology, including deviations from expected trajectories.

Contributors
Taravella, Angela, Wilson Sayres, Melissa, College of Liberal Arts and Sciences, et al.
Created Date
2016-11-29

Background The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly ...

Contributors
Sadd, Ben M., Barribeau, Seth M., Bloch, Guy, et al.
Created Date
2015-04-24