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ASU Scholarship Showcase


This growing collection consists of scholarly works authored by ASU-affiliated faculty, students and community members, and contains many open access articles. ASU-affiliated authors are encouraged to Share Your Work in the ASU Digital Repository.


Status
  • Public
Date Range
2006 2020


We present a microarray nonlinear calibration (MiNC) method for quantifying antibody binding to the surface of protein microarrays that significantly increases the linear dynamic range and reduces assay variation compared with traditional approaches. A serological analysis of guinea pig Mycobacterium tuberculosis models showed that a larger number of putative antigen targets were identified with MiNC, which is consistent with the improved assay performance of protein microarrays. MiNC has the potential to be employed in biomedical research using multiplex antibody assays that need quantitation, including the discovery of antibody biomarkers, clinical diagnostics with multi-antibody signatures, and construction of immune mathematical models.

Contributors
Yu, Xiaobo, Wallstrom, Garrick, Magee, Mitch, et al.
Created Date
2013-08-12

Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed …

Contributors
Denning, Elizabeth J., Beckstein, Oliver, College of Liberal Arts and Sciences, et al.
Created Date
2013-08-12

In this paper, we design distributed spectrum access mechanisms with both complete and incomplete network information. We propose an evolutionary spectrum access mechanism with complete network information, and show that the mechanism achieves an equilibrium that is globally evolutionarily stable. With incomplete network information, we propose a distributed learning mechanism, where each user utilizes local observations to estimate the expected throughput and learns to adjust its spectrum access strategy adaptively over time. We show that the learning mechanism converges to the same evolutionary equilibrium on the time average. Numerical results show that the proposed mechanisms achieve up to 35 percent …

Contributors
Chen, Xu, Huang, Jianwei, Ira A. Fulton Schools of Engineering, et al.
Created Date
2013-08-12

Spherical catalytic micromotors fabricated as described in Wheat et al. [Langmuir 26, 13052 ( 2010)] show fuel concentration dependent translational and rotational velocity. The motors possess short-time and long-time diffusivities that scale with the translational and rotational velocity with respect to fuel concentration. The short-time diffusivities are two to three orders of magnitude larger than the diffusivity of a Brownian sphere of the same size, increase linearly with concentration, and scale as v(2)/2 omega. The measured long-time diffusivities are five times lower than the short-time diffusivities, scale as v(2)/{2D(r)[ 1 + (omega/D-r)(2)]}, and exhibit a maximum as a function of …

Contributors
Marine, Nathan, Wheat, Philip, Ault, Jesse, et al.
Created Date
2013-08-12
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This paper considers the changes in education and capacity building that are needed in response to environmental and social challenges of the 21st Century. We argue that such changes will require more than adjustments in current educational systems, research funding strategies, and interdisciplinary collaborations. Instead, it calls for a deeper questioning of the assumptions and beliefs that frame both problems and solutions. We first discuss the challenges of transforming education and capacity building within five key arenas: interdisciplinary research; university education systems; primary and secondary education systems; researchers from the developing world; and the public at large and politicians. Our …

Contributors
O'Brien, Karen, Reams, Jonathan, Caspari, Anne, et al.
Created Date
2013-08-12

This investigation seeks to establish the practicality of numerical frame approximations. Specifically, it develops a new method to approximate the inverse frame operator and analyzes its convergence properties. It is established that sampling with well-localized frames improves both the accuracy of the numerical frame approximation as well as the robustness and efficiency of the (finite) frame operator inversion. Moreover, in applications such as magnetic resonance imaging, where the given data often may not constitute a well-localized frame, a technique is devised to project the corresponding frame data onto a more suitable frame. As a result, the target function may be …

Contributors
Song, Guohui, Gelb, Anne, College of Liberal Arts and Sciences, et al.
Created Date
2013-08-13

We describe a multi-parameter family of the minimum-uncertainty squeezed states for the harmonic oscillator in nonrelativistic quantum mechanics. They are derived by the action of the corresponding maximal kinematical invariance group on the standard ground state solution. We show that the product of the variances attains the required minimum value 1/4 only at the instances that one variance is a minimum and the other is a maximum, when the squeezing of one of the variances occurs. The generalized coherent states are explicitly constructed and their Wigner function is studied. The overlap coefficients between the squeezed, or generalized harmonic, and the …

Contributors
Kryuchkov, Sergey, Suslov, Sergei, Vega-Guzman, Jose, et al.
Created Date
2013-08-15

Explicit solutions of the inhomogeneous paraxial wave equation in a linear and quadratic approximation are applied to wave fields with invariant features, such as oscillating laser beams in a parabolic waveguide and spiral light beams in varying media. A similar effect of superfocusing of particle beams in a thin monocrystal film, harmonic oscillations of cold trapped atoms, and motion in magnetic field are also mentioned.

Contributors
Mahalov, Alex, Suazo, Erwin, Suslov, Sergei, et al.
Created Date
2013-08-15

In this paper, we study oscillating solutions of the 1D-quintic nonlinear Schrödinger equation with the help of Wigner's quasiprobability distribution in quantum phase space. An "absolute squeezing property", namely a periodic in time total localization of wave packets at some finite spatial points without violation of the Heisenberg uncertainty principle, is analyzed in this nonlinear model.

Contributors
Mahalov, Alex, Suslov, Sergei, College of Liberal Arts and Sciences, et al.
Created Date
2013-08-15

As part of a larger trend across industrialized nations, European research policy discourse has placed increasing emphasis on socio-technical integration: the explicit incorporation of activities devoted to broader social aspects into scientific activities. In order to compare these high-level integration discourses against patterns at the level of resource allocation, we analyze nearly 2500 research solicitations from the three European Framework Programmes for R&D during the period 1998-2010. We identify four distinct types of integration (socio-ethical, stakeholder, socio-economic and industrial) that occur either as core or parallel components of R&D solicitations. Quantitative analysis reveals an overall trend towards increasing integration, with …

Contributors
Rodriguez, Hannot, Fisher, Erik, Schuurbiers, Daan, et al.
Created Date
2013-08-15

A measure of shape compactness is a numerical quantity representing the degree to which a shape is compact. Ways to provide an accurate measure have been given great attention due to its application in a broad range of GIS problems, such as detecting clustering patterns from remote-sensing images, understanding urban sprawl, and redrawing electoral districts to avoid gerrymandering. In this article, we propose an effective and efficient approach to computing shape compactness based on the moment of inertia (MI), a well-known concept in physics. The mathematical framework and the computer implementation for both raster and vector models are discussed in …

Contributors
Li, Wenwen, Goodchild, Michael F., Church, Richard, et al.
Created Date
2013-08-15

Patches of deposits containing unusual mafic minerals are observed in and around some large lunar impact craters. Numerical simulations suggest that in the slowest of these impacts, asteroidal material, alien to the Moon, could have survived.

Contributors
Asphaug, Erik, College of Liberal Arts and Sciences, School of Earth and Space Exploration
Created Date
2013-08-16

This paper addresses the complex historical/political scenarios of Spanish-speaking people in the Southwestern USA and of Gaelic speakers in the Outer Hebrides. It examines (1) the historical background and current status of Spanish in the Southwestern USA and Gaelic in the Outer Hebrides; (2) comparative issues in relation to the use of dual languages; and (3) the challenges that communication in more than one prevalent language present to social work service providers. It is based on field research in the Southwestern USA (primarily Arizona) and the Comhairle nan Eilean Siar region (Outer Hebrides, Scotland). While these two areas might appear …

Contributors
Martinez-Brawley, Emilia, Zorita, Paz, Rennie, Frank, et al.
Created Date
2013-08-22

Organizational volunteering has been touted as an effective strategy for older adults to help themselves while helping others. Extending previous reviews, we carried out a meta-analysis of the relation between organizational volunteering by late-middle-aged and older adults (minimum age = 55 years old) and risk of mortality. We focused on unadjusted effect sizes (i.e., bivariate relations), adjusted effect sizes (i.e., controlling for other variables such as health), and interaction effect sizes (e.g., the joint effect of volunteering and religiosity). For unadjusted effect sizes, on average, volunteering reduced mortality risk by 47%, with a 95% confidence interval ranging from 38% to …

Contributors
Okun, Morris, Yeung, Ellen, Brown, Stephanie, et al.
Created Date
2013-09-05

The probability of large seismic events on a particular fault segment may vary due to external stress changes imparted by nearby deformation events, including other earthquakes and aseismic processes, such as fault creep and postseismic relaxation. The Hayward fault (HF), undergoing both seismic and aseismic fault slip, provides a unique opportunity to study the mutual relation of seismic and aseismic processes on a fault system. We use surface deformation data obtained from InSAR (interferometric synthetic aperture radar), creepmeters and alinement arrays, together with constraints provided by repeating earthquakes to investigate the kinematics of fault creep on the northern HF and …

Contributors
Shirzaei, Manoochehr, Buergmann, Roland, Taira, Taka'aki, et al.
Created Date
2013-09-05

Land cover change in watersheds affects the supply of a number of ecosystem services, including water supply, the production of timber and nontimber forest products, the provision of habitat for forest species, and climate regulation through carbon sequestration. The Panama Canal watershed is currently being reforested to protect the dry-season flows needed for Canal operations. Whether reforestation of the watershed is desirable depends on its impacts on all services. We develop a spatially explicit model to evaluate the implications of reforestation both for water flows and for other services. We find that reforestation does not necessarily increase water supply, but …

Contributors
Simonit, Silvio, Perrings, Charles, College of Liberal Arts and Sciences, et al.
Created Date
2013-09-05

In this paper, we study distributed scheduling in multihop multiple-input-multiple-output (MIMO) networks. We first develop a "MIMO-pipe" model that provides the upper layers a set of rates and signal-to-interference-plus-noise ratio (SINR) requirements that capture the rate-reliability tradeoff in MIMO communications. The main thrust of this paper is then dedicated to developing distributed carrier sense multiple access (CSMA) algorithms for MIMO-pipe scheduling under the SINR interference model. We choose the SINR model over the extensively studied protocol-based interference models because it more naturally captures the impact of interference in wireless networks. The coupling among the links caused by the interference under …

Contributors
Qian, Dajun, Zheng, Dong, Zhang, Junshan, et al.
Created Date
2013-09-05

To begin accounting for cultural and contextual factors related to child rearing among Mexican American parents we examined whether parents' Mexican American cultural values and perceptions of neighborhood danger influenced patterns of parenting behavior in two-parent Mexican-origin families living in the U. S. To avoid forcing Mexican American parents into a predefined model of parenting styles, we used latent profile analysis to identify unique patterns of responsiveness and demandingness among mothers and fathers. Analyses were conducted using parent self-reports on parenting and replicated with youth reports on mothers' and fathers' parenting. Across reporters, most mothers and fathers exhibited a pattern …

Contributors
White, Rebecca M. B., Zeiders, Katharine, Gonzales, Nancy, et al.
Created Date
2013-09-05

Using liquid chromatography tandem mass spectrometry, we determined the first nationwide inventories of 13 perfluoroalkyl substances (PFASs) in U.S. biosolids via analysis of samples collected by the U.S. Environmental Protection Agency in the 2001 National Sewage Sludge Survey. Perfluorooctane sulfonate [PFOS; 403 +/- 127 ng/g dry weight (dw)] was the most abundant PFAS detected in biosolids composites representing 32 U.S. states and the District of Columbia, followed by perfluorooctanoate [PFOA; 34 +/- 22 ng/g dw] and perfluorodecanoate [PFDA; 26 +/- 20 ng/g dw]. Mean concentrations in U.S. biosolids of the remaining ten PFASs ranged between 2 and 21 ng/g dw. …

Contributors
Venkatesan, Arjunkrishna, Halden, Rolf, Biodesign Institute, et al.
Created Date
2013-09-05

Information systems research is replete with examples of the importance of business processes defining IT adoption. Business processes are influenced by both organizational and operational concerns. We evaluate the comparative importance of operational and organizational influences for complementary IT systems. In the context of acute-care hospitals the analysis shows that an organizational approach to automating a process is related to different financial outcomes than an operational approach. Six complementary systems supporting a three-stage medication management process are studied: prescribing, dispensing, and administration. The analysis uses firm-level, panel data extracted from the HIMSS Analytics database spanning ten years of IT adoption …

Contributors
Spaulding, Trent J., Furukawa, Michael, Santanam, Raghu, et al.
Created Date
2013-09-05