ASU Electronic Theses and Dissertations

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Date Range
2010 2017

Multivalency is an important phenomenon that guides numerous biological interactions. It has been utilized in design of therapeutics and drug candidates. Hence, this study attempts to develop analytical tools to study multivalent interactions and design multivalent ligands for drug delivery and therapeutic applications. Atomic Force Microscopy (AFM) has been envisioned as a means of nanodiagnostics due to its single molecule sensitivity. However, the AFM based recognition imaging lacks a multiplex capacity to detect multiple analytes in a single test. Also there is no user friendly wet chemistry to functionalize AFM tips. Hence, an uncatalyzed Click Chemistry protocol was developed to ...

Contributors
Manna, Saikat, Lindsay, Stuart, Zhang, Peiming, et al.
Created Date
2016

Geopolymers, a class of X-ray amorphous, ceramic-like aluminosilicate materials are produced at ambient temperatures through a process called geopolymerization. Due to both low energy requirement during synthesis and interesting mechanical and chemical properties, geopolymers are grabbing enormous attention. Although geopolymers have a broad range of applications including thermal/acoustic insulation and waste immobilization, they are always prepared in monolithic form. The primary aim of this study is to produce new nanostructured materials from the geopolymerization process, including porous monoliths and powders. In view of the current interest in porous geopolymers for non-traditional applications, it is becoming increasingly important to develop synthetic ...

Contributors
Medpelli, Dinesh, Seo, Dong-Kyun, Herckes, Pierre, et al.
Created Date
2015

Americans spend upwards of 90% of their time indoors, hence indoor air quality (IAQ) and the impact of IAQ on human health is a major public health concern. IAQ can be negatively impacted by outdoor pollution infiltrating indoors, the emission of indoor pollutants, indoor atmospheric chemistry and poor ventilation. Energy saving measures like retrofits to seal the building envelope to prevent the leakage of heated or cooled air will impact IAQ. However, existing studies have been inconclusive as to whether increased energy efficiency is leading to detrimental IAQ. In this work, field campaigns were conducted in apartment homes in Phoenix, ...

Contributors
Frey, Sarah Elizabeth, Herckes, Pierre, Fraser, Matthew P, et al.
Created Date
2014

Broadband dielectric spectroscopy is a powerful technique for understanding the dynamics in supercooled liquids. It generates information about the timescale of the orientational motions of molecular dipoles within the liquid. However, dynamics of liquids measured in the non-linear response regime has recently become an area of significant interest, because additional information can be obtained compared with linear response measurements. The first part of this thesis describes nonlinear dielectric relaxation experiments performed on various molecular glass forming-liquids, with an emphasis on the response at high frequencies (excess wing). A significant nonlinear dielectric effect (NDE) was found to persist in these modes, ...

Contributors
Samanta, Subarna, Richert, Ranko, Steimle, Timothy, et al.
Created Date
2016

As sunlight is an ideal source of energy on a global scale, there are several approaches being developed to harvest it and convert it to a form that can be used. One of these is though mimicking the processes in natural photosynthesis. Artificial photosynthetic systems include dye sensitized solar cells for the conversion of sunlight to electricity, and photoelectrosynthetic cells which use sunlight to drive water oxidation and hydrogen production to convert sunlight to energy stored in fuel. Both of these approaches include the process of the conversion of light energy into chemical potential in the form of a charge-separated ...

Contributors
Antoniuk-Pablant, Antaeres, Gust, Devens, Moore, Ana L, et al.
Created Date
2015

The biological and chemical diversity of protein structure and function can be greatly expanded by position-specific incorporation of non-natural amino acids bearing a variety of functional groups. Non-cognate amino acids can be incorporated into proteins at specific sites by using orthogonal aminoacyl-tRNA synthetase/tRNA pairs in conjunction with nonsense, rare, or 4-bp codons. There has been considerable progress in developing new types of amino acids, in identifying novel methods of tRNA aminoacylation, and in expanding the genetic code to direct their position. Chemical aminoacylation of tRNAs is accomplished by acylation and ligation of a dinucleotide (pdCpA) to the 3'-terminus of truncated ...

Contributors
Nangreave, Ryan Christopher, Hecht, Sidney M, Yan, Hao, et al.
Created Date
2013

In anthropological models of social organization, kinship is perceived to be fundamental to social structure. This project aimed to understand how individuals buried in neighborhoods or patio groups were affiliated, by considering multiple possibilities of fictive and biological kinship, short or long-term co-residence, and long-distance kin affiliation. The social organization of the ancient Maya urban center of Copan, Honduras during the Late Classic (AD 600-822) period was evaluated through analysis of the human skeletal remains drawn from the largest collection yet recovered in Mesoamerica (n=1200). The research question was: What are the roles that kinship (biological or fictive) and co-residence ...

Contributors
Miller, Katherine Anne, Buikstra, Jane E, Bell, Ellen E, et al.
Created Date
2015

Humanity’s demand for energy is increasing exponentially and the dependence on fossil fuels is both unsustainable and detrimental to the environment. To provide a solution to the impending energy crisis, it is reasonable to look toward utilizing solar energy, which is abundant and renewable. One approach to harvesting solar irradiation for fuel purposes is through mimicking the processes of natural photosynthesis in an artificial design to use sunlight and water to store energy in chemical bonds for later use. Thus, in order to design an efficient energy conversion device, the underlying processes of the natural system must be understood. An ...

Contributors
Brown, Chelsea Lynn, Moore, Ana L, Gust, Devens, et al.
Created Date
2015

Pedagogical content knowledge (PCK) has been described as the knowledge teachers' use in the process of designing and implementing lessons to a particular group of students. This includes the most effective representations that make the content understandable to students, together with the preconceptions and misconceptions that students hold. For chemistry, students have been found to have difficulty with the discipline due to its reliance upon three levels of representation called the triplet: the macro, the submicro, and the symbolic. This study examines eight beginning chemistry teachers' depiction of the chemistry content through the triplet relationship and modifications as a result ...

Contributors
Adams, Krista Lynn, Luft, Julie A., Baker, Dale, et al.
Created Date
2012

Cell heterogeneity is widely present in the biological world and exists even in an isogenic population. Resolving the protein heterogeneity at the single cell level is of enormous biological and clinical relevance. However, single cell protein analysis has proven to be challenging due to extremely low amount of protein in a single cell and the huge complexity of proteome. This requires appropriate sampling and sensitive detection techniques. Here, a new approach, microfluidics combined with MALDI-TOF mass spectrometry was brought forward, for the analysis of proteins in single cells. The detection sensitivity of peptides as low as 300 molecules and of ...

Contributors
Yang, Mian, Ros, Alexandra, Hayes, Mark, et al.
Created Date
2016

This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.

In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.

Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries.

For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.