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ASU Electronic Theses and Dissertations


This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.

In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.

Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.


Contributor
Date Range
2010 2019


This thesis presents a multi-modal motion tracking system for stroke patient rehabilitation. This system deploys two sensor modules: marker-based motion capture system and inertial measurement unit (IMU). The integrated system provides real-time measurement of the right arm and trunk movement, even in the presence of marker occlusion. The information from the two sensors is fused through quaternion-based recursive filters to promise robust detection of torso compensation (undesired body motion). Since this algorithm allows flexible sensor configurations, it presents a framework for fusing the IMU data and vision data that can adapt to various sensor selection scenarios. The proposed system consequently …

Contributors
Liu, Yangzi, Qian, Gang, Olson, Loren, et al.
Created Date
2010

An advantage of doubly fed induction generators (DFIGs) as compared to conventional fixed speed wind turbine generators is higher efficiency. This higher efficiency is achieved due to the ability of the DFIG to operate near its optimal turbine efficiency over a wider range of wind speeds through variable speed operation. This is achieved through the application of a back-to-back converter that tightly controls the rotor current and allows for asynchronous operation. In doing so, however, the power electronic converter effectively decouples the inertia of the turbine from the system. Hence, with the increase in penetration of DFIG based wind farms, …

Contributors
Gautam, Durga, Vittal, Vijay, Heydt, Gerald, et al.
Created Date
2010

A systematic top down approach to minimize risk and maximize the profits of an investment over a given period of time is proposed. Macroeconomic factors such as Gross Domestic Product (GDP), Consumer Price Index (CPI), Outstanding Consumer Credit, Industrial Production Index, Money Supply (MS), Unemployment Rate, and Ten-Year Treasury are used to predict/estimate asset (sector ETF`s) returns. Fundamental ratios of individual stocks are used to predict the stock returns. An a priori known cash-flow sequence is assumed available for investment. Given the importance of sector performance on stock performance, sector based Exchange Traded Funds (ETFs) for the S&P; and Dow …

Contributors
Chitturi, Divakar, Rodriguez, Armando, Tsakalis, Konstantinos S, et al.
Created Date
2010

There is increasing interest in the medical and behavioral health communities towards developing effective strategies for the treatment of chronic diseases. Among these lie adaptive interventions, which consider adjusting treatment dosages over time based on participant response. Control engineering offers a broad-based solution framework for optimizing the effectiveness of such interventions. In this thesis, an approach is proposed to develop dynamical models and subsequently, hybrid model predictive control schemes for assigning optimal dosages of naltrexone, an opioid antagonist, as treatment for a chronic pain condition known as fibromyalgia. System identification techniques are employed to model the dynamics from the daily …

Contributors
Deshpande, Sunil, Rivera, Daniel E., Si, Jennie, et al.
Created Date
2011

Due to restructuring and open access to the transmission system, modern electric power systems are being operated closer to their operational limits. Additionally, the secure operational limits of modern power systems have become increasingly difficult to evaluate as the scale of the network and the number of transactions between utilities increase. To account for these challenges associated with the rapid expansion of electric power systems, dynamic equivalents have been widely applied for the purpose of reducing the computational effort of simulation-based transient security assessment. Dynamic equivalents are commonly developed using a coherency-based approach in which a retained area and an …

Contributors
Ma, Feng, Vittal, Vijay, Tylavsky, Daniel, et al.
Created Date
2011

Proportional-Integral-Derivative (PID) controllers are a versatile category of controllers that are commonly used in the industry as control systems due to the ease of their implementation and low cost. One problem that continues to intrigue control designers is the matter of finding a good combination of the three parameters - P, I and D of these controllers so that system stability and optimum performance is achieved. Also, a certain amount of robustness to the process is expected from the PID controllers. In the past, many different methods for tuning PID parameters have been developed. Some notable techniques are the Ziegler-Nichols, …

Contributors
Shafique, Md Ashfaque Bin, Tsakalis, Konstantinos S., Rodriguez, Armando A., et al.
Created Date
2011

The ability to plan, execute, and control goal oriented reaching and grasping movements is among the most essential functions of the brain. Yet, these movements are inherently variable; a result of the noise pervading the neural signals underlying sensorimotor processing. The specific influences and interactions of these noise processes remain unclear. Thus several studies have been performed to elucidate the role and influence of sensorimotor noise on movement variability. The first study focuses on sensory integration and movement planning across the reaching workspace. An experiment was designed to examine the relative contributions of vision and proprioception to movement planning by …

Contributors
Apker, Gregory, Buneo, Christopher A, Helms Tillery, Stephen, et al.
Created Date
2012

Contemporary methods for dynamic security assessment (DSA) mainly re-ly on time domain simulations to explore the influence of large disturbances in a power system. These methods are computationally intensive especially when the system operating point changes continually. The trajectory sensitivity method, when implemented and utilized as a complement to the existing DSA time domain simulation routine, can provide valuable insights into the system variation in re-sponse to system parameter changes. The implementation of the trajectory sensitivity analysis is based on an open source power system analysis toolbox called PSAT. Eight categories of sen-sitivity elements have been implemented and tested. The …

Contributors
Hou, Guanji, Vittal, Vijay, Heydt, Gerald, et al.
Created Date
2012

This dissertation includes two parts. First it focuses on discussing robust signal processing algorithms, which lead to consistent performance under perturbation or uncertainty in video target tracking applications. Projective distortion plagues the quality of long sequence mosaicking which results in loosing important target information. Some correction techniques require prior information. A new algorithm is proposed in this dissertation to this very issue. Optimization and parameter tuning of a robust camera motion estimation as well as implementation details are discussed for a real-time application using an ordinary general-purpose computer. Performance evaluations on real-world unmanned air vehicle (UAV) videos demonstrate the robustness …

Contributors
Yang, Chenhui, Si, Jennie, Jassemidis, Leonidas, et al.
Created Date
2012

Interictal spikes, together with seizures, have been recognized as the two hallmarks of epilepsy, a brain disorder that 1% of the world's population suffers from. Even though the presence of spikes in brain's electromagnetic activity has diagnostic value, their dynamics are still elusive. It was an objective of this dissertation to formulate a mathematical framework within which the dynamics of interictal spikes could be thoroughly investigated. A new epileptic spike detection algorithm was developed by employing data adaptive morphological filters. The performance of the spike detection algorithm was favorably compared with others in the literature. A novel spike spatial synchronization …

Contributors
Krishnan, Balu, Iasemidis, Leonidas, Tsakalis, Kostantinos, et al.
Created Date
2012

This report provides an overview of scramjet-powered hypersonic vehicle modeling and control challenges. Such vehicles are characterized by unstable non-minimum phase dynamics with significant coupling and low thrust margins. Recent trends in hypersonic vehicle research are summarized. To illustrate control relevant design issues and tradeoffs, a generic nonlinear 3DOF longitudinal dynamics model capturing aero-elastic-propulsive interactions for wedge-shaped vehicle is used. Limitations of the model are discussed and numerous modifications have been made to address control relevant needs. Two different baseline configurations are examined over a two-stage to orbit ascent trajectory. The report highlights how vehicle level-flight static (trim) and dynamic …

Contributors
Dickeson, Jeffrey James, Rodriguez, Armando A, Tsakalis, Konstantinos, et al.
Created Date
2012

In electric power systems, phasor measurement units (PMUs) are capable of providing synchronized voltage and current phasor measurements which are superior to conventional measurements collected by the supervisory control and data acquisition (SCADA) system in terms of resolution and accuracy. These measurements are known as synchrophasor measurements. Considerable research work has been done on the applications of PMU measurements based on the as-sumption that a high level of accuracy is obtained in the field. The study in this dissertation is conducted to address the basic issue concerning the accuracy of actual PMU measurements in the field. Synchronization is one of …

Contributors
Zhang, Qing, Heydt, Gerald, Vittal, Vijay, et al.
Created Date
2012

Photovoltaic (PV) power generation has the potential to cause a significant impact on power system reliability since its total installed capacity is projected to increase at a significant rate. PV generation can be described as an intermittent and variable resource because its production is influenced by ever-changing environmental conditions. The study in this dissertation focuses on the influence of PV generation on trans-mission system reliability. This is a concern because PV generation output is integrated into present power systems at various voltage levels and may significantly affect the power flow patterns. This dissertation applies a probabilistic power flow (PPF) algorithm …

Contributors
Fan, Miao, Vittal, Vijay, Heydt, Gerald Thomas, et al.
Created Date
2012

With the rapid growth of power systems and the concomitant technological advancements, the goal of achieving smart grids is no longer a vision but a foreseeable reality. Hence, the existing grids are undergoing infrastructural modifications to achieve the diverse characteristics of a smart grid. While there are many subjects associated with the operation of smart grids, this dissertation addresses two important aspects of smart grids: increased penetration of renewable resources, and increased reliance on sensor systems to improve reliability and performance of critical power system components. Present renewable portfolio standards are changing both structural and performance characteristics of power systems …

Contributors
Eftekharnejad, Sara, Heydt, Gerald, Vittal, Vijay, et al.
Created Date
2012

The combined heat and power (CHP)-based distributed generation (DG) or dis-tributed energy resources (DERs) are mature options available in the present energy mar-ket, considered to be an effective solution to promote energy efficiency. In the urban en-vironment, the electricity, water and natural gas distribution networks are becoming in-creasingly interconnected with the growing penetration of the CHP-based DG. Subse-quently, this emerging interdependence leads to new topics meriting serious consideration: how much of the CHP-based DG can be accommodated and where to locate these DERs, and given preexisting constraints, how to quantify the mutual impacts on operation performances between these urban energy …

Contributors
Zhang, Xianjun, Karady, George G., Ariaratnam, Samuel T., et al.
Created Date
2013

Under the framework of intelligent management of power grids by leveraging advanced information, communication and control technologies, a primary objective of this study is to develop novel data mining and data processing schemes for several critical applications that can enhance the reliability of power systems. Specifically, this study is broadly organized into the following two parts: I) spatio-temporal wind power analysis for wind generation forecast and integration, and II) data mining and information fusion of synchrophasor measurements toward secure power grids. Part I is centered around wind power generation forecast and integration. First, a spatio-temporal analysis approach for short-term wind …

Contributors
He, Miao, Zhang, Junshan, Vittal, Vijay, et al.
Created Date
2013

This study focuses on state estimation of nonlinear discrete time systems with constraints. Physical processes have inherent in them, constraints on inputs, outputs, states and disturbances. These constraints can provide additional information to the estimator in estimating states from the measured output. Recursive filters such as Kalman Filters or Extended Kalman Filters are commonly used in state estimation; however, they do not allow inclusion of constraints in their formulation. On the other hand, computational complexity of full information estimation (using all measurements) grows with iteration and becomes intractable. One way of formulating the recursive state estimation problem with constraints is …

Contributors
Joshi, Rakesh, Tsakalis, Konstantinos, Rodriguez, Armando, et al.
Created Date
2013

This thesis discusses control and obstacle avoidance for non-holonomic differential drive mobile vehicles. The two important behaviors for the vehicle can be defined as go to goal and obstacle avoidance behavior. This thesis discusses both behaviors in detail. Go to goal behavior is the ability of the mobile vehicle to go from one particular co-ordinate to another. Cruise control, cartesian and posture stabilization problems are discussed as the part of this behavior. Control strategies used for the above three problems are explained in the thesis. Matlab simulations are presented to verify these controllers. Obstacle avoidance behavior ensures that the vehicle …

Contributors
Chopra, Dhruv, Rodriguez, Armando A, Tsakalis, Konstantinos, et al.
Created Date
2013

The problem of systematically designing a control system continues to remain a subject of intense research. In this thesis, a very powerful control system design environment for Linear Time-Invariant (LTI) Multiple-Input Multiple-Output (MIMO) plants is presented. The environment has been designed to address a broad set of closed loop metrics and constraints; e.g. weighted H-infinity closed loop performance subject to closed loop frequency and/or time domain constraints (e.g. peak frequency response, peak overshoot, peak controls, etc.). The general problem considered - a generalized weighted mixed-sensitivity problem subject to constraints - permits designers to directly address and tradeoff multivariable properties at …

Contributors
Puttannaiah, Karan, Rodriguez, Armando A, Tsakalis, Konstantinos S, et al.
Created Date
2013

This dissertation considers an integrated approach to system design and controller design based on analyzing limits of system performance. Historically, plant design methodologies have not incorporated control relevant considerations. Such an approach could result in a system that might not meet its specifications (or one that requires a complex control architecture to do so). System and controller designers often go through several iterations in order to converge to an acceptable plant and controller design. The focus of this dissertation is on the design and control an air-breathing hypersonic vehicle using such an integrated system-control design framework. The goal is to …

Contributors
Sridharan, Srikanth, Rodriguez, Armando A, Mittelmann, Hans D, et al.
Created Date
2014

This thesis presents approaches to develop micro seismometers and accelerometers based on molecular electronic transducers (MET) technology using MicroElectroMechanical Systems (MEMS) techniques. MET is a technology applied in seismic instrumentation that proves highly beneficial to planetary seismology. It consists of an electrochemical cell that senses the movement of liquid electrolyte between electrodes by converting it to the output current. MET seismometers have advantages of high sensitivity, low noise floor, small size, absence of fragile mechanical moving parts and independence on the direction of sensitivity axis. By using MEMS techniques, a micro MET seismometer is developed with inter-electrode spacing close to …

Contributors
Huang, Hai, Yu, Hongyu, Jiang, Hanqing, et al.
Created Date
2014

With growing complexity of power grid interconnections, power systems may become increasingly vulnerable to low frequency oscillations (especially inter-area oscillations) and dependent on stabilizing controls using either local signals or wide-area signals to provide adequate damping. In recent years, the ability and potential to use wide-area signals for control purposes has increased since a significant investment has been made in the U. S. in deploying synchrophasor measurement technology. Fast and reliable communication systems are essential to enable the use of wide-area signals in controls. If wide-area signals find increased applicability in controls the security and reliability of power systems could …

Contributors
Zhang, Song, Vittal, Vijay, Heydt, Gerald, et al.
Created Date
2014

The basal ganglia are four sub-cortical nuclei associated with motor control and reward learning. They are part of numerous larger mostly segregated loops where the basal ganglia receive inputs from specific regions of cortex. Converging on these inputs are dopaminergic neurons that alter their firing based on received and/or predicted rewarding outcomes of a behavior. The basal ganglia's output feeds through the thalamus back to the areas of the cortex where the loop originated. Understanding the dynamic interactions between the various parts of these loops is critical to understanding the basal ganglia's role in motor control and reward based learning. …

Contributors
Baldwin, Nathan A., Helms Tillery, Stephen I, Castañeda, Edward, et al.
Created Date
2014

Learning by trial-and-error requires retrospective information that whether a past action resulted in a rewarded outcome. Previous outcome in turn may provide information to guide future behavioral adjustment. But the specific contribution of this information to learning a task and the neural representations during the trial-and-error learning process is not well understood. In this dissertation, such learning is analyzed by means of single unit neural recordings in the rats' motor agranular medial (AGm) and agranular lateral (AGl) while the rats learned to perform a directional choice task. Multichannel chronic recordings using implanted microelectrodes in the rat's brain were essential to …

Contributors
Yuan, Yuan, Si, Jennie, Buneo, Christopher, et al.
Created Date
2014

Animals learn to choose a proper action among alternatives according to the circumstance. Through trial-and-error, animals improve their odds by making correct association between their behavioral choices and external stimuli. While there has been an extensive literature on the theory of learning, it is still unclear how individual neurons and a neural network adapt as learning progresses. In this dissertation, single units in the medial and lateral agranular (AGm and AGl) cortices were recorded as rats learned a directional choice task. The task required the rat to make a left/right side lever press if a light cue appeared on the …

Contributors
Mao, Hongwei, Si, Jennie, Buneo, Christopher, et al.
Created Date
2014

Increasing interest in individualized treatment strategies for prevention and treatment of health disorders has created a new application domain for dynamic modeling and control. Standard population-level clinical trials, while useful, are not the most suitable vehicle for understanding the dynamics of dosage changes to patient response. A secondary analysis of intensive longitudinal data from a naltrexone intervention for fibromyalgia examined in this dissertation shows the promise of system identification and control. This includes datacentric identification methods such as Model-on-Demand, which are attractive techniques for estimating nonlinear dynamical systems from noisy data. These methods rely on generating a local function approximation …

Contributors
Deshpande, Sunil, Rivera, Daniel E., Peet, Matthew M., et al.
Created Date
2014

To uncover the neural correlates to go-directed behavior, single unit action potentials are considered fundamental computing units and have been examined by different analytical methodologies under a broad set of hypotheses. Using a behaving rat performing a directional choice learning task, we aim to study changes in rat's cortical neural patterns while he improved his task performance accuracy from chance to 80% or higher. Specifically, simultaneous multi-channel single unit neural recordings from the rat's agranular medial (AGm) and Agranular lateral (AGl) cortices were analyzed using joint peristimulus time histogram (JPSTHs), which effectively unveils firing coincidences in neural action potentials. My …

Contributors
Cheng, Bing, Si, Jennie, Chae, Junseok, et al.
Created Date
2014

Control engineering offers a systematic and efficient approach to optimizing the effectiveness of individually tailored treatment and prevention policies, also known as adaptive or ``just-in-time'' behavioral interventions. These types of interventions represent promising strategies for addressing many significant public health concerns. This dissertation explores the development of decision algorithms for adaptive sequential behavioral interventions using dynamical systems modeling, control engineering principles and formal optimization methods. A novel gestational weight gain (GWG) intervention involving multiple intervention components and featuring a pre-defined, clinically relevant set of sequence rules serves as an excellent example of a sequential behavioral intervention; it is examined in …

Contributors
Dong, Yuwen, Rivera, Daniel E, Dai, Lenore, et al.
Created Date
2014

Gas turbine engine for aircraft propulsion represents one of the most physics-complex and safety-critical systems in the world. Its failure diagnostic is challenging due to the complexity of the model system, difficulty involved in practical testing and the infeasibility of creating homogeneous diagnostic performance evaluation criteria for the diverse engine makes. NASA has designed and publicized a standard benchmark problem for propulsion engine gas path diagnostic that enables comparisons among different engine diagnostic approaches. Some traditional model-based approaches and novel purely data-driven approaches such as machine learning, have been applied to this problem. This study focuses on a different machine …

Contributors
Wu, Qiyu, Si, Jennie, Wu, Teresa, et al.
Created Date
2015

This thesis addresses the design and control of three phase inverters. Such inverters are used to produce three-phase sinusoidal voltages and currents from a DC source. They are critical for injecting power from renewable energy sources into the grid. This is especially true since many of these sources of energy are DC sources (e.g. solar photovoltaic) or need to be stored in DC batteries because they are intermittent (e.g. wind and solar). Two classes of inverters are examined in this thesis. A control-centric design procedure is presented for each class. The first class of inverters is simple in that they …

Contributors
Sarkar, Aratrik, Rodriguez, Armando A., Si, Jennie, et al.
Created Date
2015

This thesis addresses control design for fixed-wing air-breathing aircraft. Four aircraft with distinct dynamical properties are considered: a scram-jet powered hypersonic (100foot long, X-43 like, wedge shaped) aircraft with flexible modes operating near Mach 8, 85k ft, a NASA HiMAT (Highly Maneuverable Aircraft Technology) F-18 aircraft, a McDonnell Douglas AV-8A Harrier aircraft, and a Vought F-8 Crusader aircraft. A two-input two-output (TITO) longitudinal LTI (linear time invariant) dynamical model is used for each aircraft. Control design trade studies are conducted for each of the aircraft. Emphasis is placed on the hypersonic vehicle because of its complex nonlinear (unstable, non-minimum phase, …

Contributors
Mondal, Kaustav, Rodriguez, Armando Antonio, Tsakalis, Kostas, et al.
Created Date
2015

Toward the ambitious long-term goal of a fleet of cooperating Flexible Autonomous Machines operating in an uncertain Environment (FAME), this thesis addresses several critical modeling, design and control objectives for ground vehicles. One central objective was to show how off-the-shelf (low-cost) remote-control (RC) “toy” vehicles can be converted into intelligent multi-capability robotic-platforms for conducting FAME research. This is shown for two vehicle classes: (1) six differential-drive (DD) RC vehicles called Thunder Tumbler (DDTT) and (2) one rear-wheel drive (RWD) RC car called Ford F-150 (1:14 scale). Each DDTT-vehicle was augmented to provide a substantive suite of capabilities as summarized below …

Contributors
Lin, Zhenyu, Rodriguez, Armando Antonio, Rodriguez, Armando Antonio, et al.
Created Date
2015

Brain-machine interfaces (BMIs) were first imagined as a technology that would allow subjects to have direct communication with prosthetics and external devices (e.g. control over a computer cursor or robotic arm movement). Operation of these devices was not automatic, and subjects needed calibration and training in order to master this control. In short, learning became a key component in controlling these systems. As a result, BMIs have become ideal tools to probe and explore brain activity, since they allow the isolation of neural inputs and systematic altering of the relationships between the neural signals and output. I have used BMIs …

Contributors
Armenta Salas, Michelle, Helms Tillery, Stephen I, Si, Jennie, et al.
Created Date
2015

Mechanical properties of cells are important in maintaining physiological functions of biological systems. Quantitative measurement and analysis of mechanical properties can help understand cellular mechanics and its functional relevance and discover physical biomarkers for diseases monitoring and therapeutics. This dissertation presents a work to develop optical methods for studying cell mechanics which encompasses four applications. Surface plasmon resonance microscopy based optical method has been applied to image intracellular motions and cell mechanical motion. This label-free technique enables ultrafast imaging with extremely high sensitivity in detecting cell deformation. The technique was first applied to study intracellular transportation. Organelle transportation process and …

Contributors
Yang, Yunze, Tao, Nongjian, Wang, Shaopeng, et al.
Created Date
2016

Recent new experiments showed that wide-field imaging at millimeter scale is capable of recording hundreds of neurons in behaving mice brain. Monitoring hundreds of individual neurons at a high frame rate provides a promising tool for discovering spatiotemporal features of large neural networks. However, processing the massive data sets is impossible without automated procedures. Thus, this thesis aims at developing a new tool to automatically segment and track individual neuron cells. The new method used in this study employs two major ideas including feature extraction based on power spectral density of single neuron temporal activity and clustering tree to separate …

Contributors
Wu, Ruofan, Si, Jennie, Sadleir, Rosalind, et al.
Created Date
2016

The purpose of this dissertation is to develop a design technique for fractional PID controllers to achieve a closed loop sensitivity bandwidth approximately equal to a desired bandwidth using frequency loop shaping techniques. This dissertation analyzes the effect of the order of a fractional integrator which is used as a target on loop shaping, on stability and performance robustness. A comparison between classical PID controllers and fractional PID controllers is presented. Case studies where fractional PID controllers have an advantage over classical PID controllers are discussed. A frequency-domain loop shaping algorithm is developed, extending past results from classical PID’s that …

Contributors
Saleh, Khalid M, Tsakalis, Konstantinos, Rodriguez, Armando, et al.
Created Date
2017

This dissertation is focused on developing an algorithm to provide current state estimation and future state predictions for biomechanical human walking features. The goal is to develop a system which is capable of evaluating the current action a subject is taking while walking and then use this to predict the future states of biomechanical features. This work focuses on the exploration and analysis of Interaction Primitives (Amor er al, 2014) and their relevance to biomechanical prediction for human walking. Built on the framework of Probabilistic Movement Primitives, Interaction Primitives utilize an EKF SLAM algorithm to localize and map a distribution …

Contributors
Clark, Geoffrey Mitchell, Ben Amor, Heni, Si, Jennie, et al.
Created Date
2018

Unmanned aerial vehicles (UAVs) are widely used in many applications because of their small size, great mobility and hover performance. This has been a consequence of the fast development of electronics, cheap lightweight flight controllers for accurate positioning and cameras. This thesis describes modeling, control and design of an oblique-cross-quadcopter platform for indoor-environments. One contribution of the work was the design of a new printed-circuit-board (PCB) flight controller (called MARK3). Key features/capabilities are as follows: (1) a Teensy 3.2 microcontroller with 168MHz overclock –used for communications, full-state estimation and inner-outer loop hierarchical rate-angle-speed-position control, (2) an on-board MEMS inertial-measurement-unit (IMU) …

Contributors
Lu, Shi, Rodriguez, Armando A., Tsakalis, Konstantinos, et al.
Created Date
2018

Spike sorting is a critical step for single-unit-based analysis of neural activities extracellularly and simultaneously recorded using multi-channel electrodes. When dealing with recordings from very large numbers of neurons, existing methods, which are mostly semiautomatic in nature, become inadequate. This dissertation aims at automating the spike sorting process. A high performance, automatic and computationally efficient spike detection and clustering system, namely, the M-Sorter2 is presented. The M-Sorter2 employs the modified multiscale correlation of wavelet coefficients (MCWC) for neural spike detection. At the center of the proposed M-Sorter2 are two automatic spike clustering methods. They share a common hierarchical agglomerative modeling …

Contributors
Ma, Weichao, Si, Jennie, Papandreou-Suppappola, Antonia, et al.
Created Date
2019

Stroke remains a leading cause of adult disability in the United States. In recent studies, chronic vagus nerve stimulation (VNS) has been proven to enhance functional recovery when paired with motor rehabilitation training after stroke. Other studies have also demonstrated that delivering VNS during the onset of a stroke may elicit some neuroprotective effects as observed in remaining neural tissue and motor function. While these studies have demonstrated the benefits of VNS as a treatment or therapy in combatting stroke damage, the mechanisms responsible for these effects are still not well understood or known. The aim of this research was …

Contributors
Okada, Kristen Yuri, Kleim, Jeffrey A, Si, Jennie, et al.
Created Date
2019