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ASU Electronic Theses and Dissertations


This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.

In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.

Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.


Contributor
Language
  • English
Date Range
2011 2019


Understanding the consequences of changes in social networks is an important an- thropological research goal. This dissertation looks at the role of data-driven social networks on infectious disease transmission and evolution. The dissertation has two projects. The first project is an examination of the effects of the superspreading phenomenon, wherein a relatively few individuals are responsible for a dispropor- tionate number of secondary cases, on the patterns of an infectious disease. The second project examines the timing of the initial introduction of tuberculosis (TB) to the human population. The results suggest that TB has a long evolutionary history with hunter-gatherers. …

Contributors
Nesse, Hans P, Hurtado, Ana Magdalena, Castillo-Chavez, Carlos, et al.
Created Date
2019

The most advanced social insects, the eusocial insects, form often large societies in which there is reproductive division of labor, queens and workers, have overlapping generations, and cooperative brood care where daughter workers remain in the nest with their queen mother and care for their siblings. The eusocial insects are composed of representative species of bees and wasps, and all species of ants and termites. Much is known about their organizational structure, but remains to be discovered. The success of social insects is dependent upon cooperative behavior and adaptive strategies shaped by natural selection that respond to internal or external …

Contributors
Rodriguez Messan, Marisabel, Kang, Yun, Castillo-Chavez, Carlos, et al.
Created Date
2018

This dissertation explores the impact of environmental dependent risk on disease dynamics within a Lagrangian modeling perspective; where the identity (defined by place of residency) of individuals is preserved throughout the epidemic process. In Chapter Three, the impact of individuals who refuse to be vaccinated is explored. MMR vaccination and birth rate data from the State of California are used to determine the impact of the anti-vaccine movement on the dynamics of growth of the anti-vaccine sub-population. Dissertation results suggest that under realistic California social dynamics scenarios, it is not possible to revert the influence of anti-vaccine contagion. In Chapter …

Contributors
Moreno Martinez, Victor Manuel, Castillo-Chavez, Carlos, Kang, Yun, et al.
Created Date
2018

Diabetes is a disease characterized by reduced insulin action and secretion, leading to elevated blood glucose. In the 1990s, studies showed that intravenous injection of fatty acids led to a sharp negative response in insulin action that subsided hours after the injection. The molecule associated with diminished insulin signalling response was a byproduct of fatty acids, diacylglycerol. This dissertation is focused on the formulation of a model built around the known mechanisms of glucose and fatty acid storage and metabolism within myocytes, as well as downstream effects of diacylglycerol on insulin action. Data from euglycemic-hyperinsulinemic clamp with fatty acid infusion …

Contributors
Burkow, Daniel Harrison, Li, Jiaxu, Castillo-Chavez, Carlos, et al.
Created Date
2017

Foraging strategies in social animals are often shaped by change in an organism's natural surrounding. Foraging behavior can hence be highly plastic, time, and condition dependent. The motivation of my research is to explore the effects of dispersal behavior in predators or parasites on population dynamics in heterogeneous environments by developing varied models in different contexts through closely working with ecologists. My models include Ordinary Differential Equation (ODE)-type meta population models and Delay Differential Equation (DDE) models with validation through data. I applied dynamical theory and bifurcation theory with carefully designed numerical simulations to have a better understanding on the …

Contributors
Messan, Komi Segno, Kang, Yun, Castillo-Chavez, Carlos, et al.
Created Date
2017

Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer type worldwide, accounts for more than 630,000 new cases and 350,000 deaths annually. Drug-resistance and tumor recurrence are the most challenging problems in head and neck cancer treatment. It is hypothesized that a very small fraction of stem-like cells within HNSCC tumor, called cancer stem cells (CSCs), is responsible for tumor initiation, progression, resistance and recurrence. It has also been shown that IL-6 secreted by head and neck tumor-associated endothelial cells (ECs) enhances the survival, self-renewal and tumorigenic potential of head and neck CSCs. In this study we …

Contributors
Nazari, Fereshteh, Jackson, Trachette L., Jackson, Trachette L., et al.
Created Date
2017

This dissertation will look at large scale collaboration through the lens of online communities to answer questions about what makes a collaboration persist. Results address how collaborations attract contributions, behaviors that could give rise to patterns seen in the data, and the properties of collaborations that drive those behaviors. It is understood that collaborations, online and otherwise, must retain users to remain productive. However, before users can be retained they must be recruited. In the first project, a few necessary properties of the ``attraction'' function are identified by constraining the dynamics of an ODE (Ordinary Differential Equation) model. Additionally, more …

Contributors
Manning, Miles, Janssen, Marcus A, Castillo-Chavez, Carlos, et al.
Created Date
2017

This dissertation discusses the Cournot competition and competitions in the exploitation of common pool resources and its extension to the tragedy of the commons. I address these models by using potential games and inquire how these models reflect the real competitions for provisions of environmental resources. The Cournot models are dependent upon how many firms there are so that the resultant Cournot-Nash equilibrium is dependent upon the number of firms in oligopoly. But many studies do not take into account how the resultant Cournot-Nash equilibrium is sensitive to the change of the number of firms. Potential games can find out …

Contributors
Mamada, Robert Hideo, Perrings, Charles, Castillo-Chavez, Carlos, et al.
Created Date
2017

A key factor in the success of social animals is their organization of work. Mathematical models have been instrumental in unraveling how simple, individual-based rules can generate collective patterns via self-organization. However, existing models offer limited insights into how these patterns are shaped by behavioral differences within groups, in part because they focus on analyzing specific rules rather than general mechanisms that can explain behavior at the individual-level. My work argues for a more principled approach that focuses on the question of how individuals make decisions in costly environments. In Chapters 2 and 3, I demonstrate how this approach provides …

Contributors
Udiani, Oyita Udiani, Kang, Yun, Fewell, Jennifer H, et al.
Created Date
2016

The immune system plays a dual role during neoplastic progression. It can suppress tumor growth by eliminating cancer cells, and also promote neoplastic expansion by either selecting for tumor cells that are fitter to survive in an immunocompetent host or by establishing the right conditions within the tumor microenvironment. First, I present a model to study the dynamics of subclonal evolution of cancer. I model selection through time as an epistatic process. That is, the fitness change in a given cell is not simply additive, but depends on previous mutations. Simulation studies indicate that tumors are composed of myriads of …

Contributors
Chowell, Diego, Castillo-Chavez, Carlos, Anderson, Karen S, et al.
Created Date
2016