ASU Electronic Theses and Dissertations
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Collective cell migration in the 3D fibrous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response and cancer progression. A migrating cell also generates active pulling forces, which are transmitted to the ECM fibers via focal adhesion complexes. Such active forces consistently remodel the local ECM (e.g., by re-orienting the collagen fibers, forming fiber bundles and increasing the local stiffness of ECM), leading to a dynamically evolving force network in the system that in turn regulates the collective migration of cells. In this work, this novel mechanotaxis mechanism is investigated, i.e., the …
- Nan, Hanqing, Jiao, Yang, Alford, Terry, et al.
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