ASU Electronic Theses and Dissertations
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Drosophila CORL (dCORL) is a central nervous system (CNS)-specific gene that is hypothesized to function in Transforming Growth Factor β signaling. It is part of the Corl multigene family that includes mouse and human homologs. dCORL is necessary for Ecdysone Receptor isoform B1 (EcR-B1) protein expression in the mushroom body, a brain region responsible for learning and memory. Beyond this, dCORL function is unknown. As dCORL expression is restricted to the CNS, co-expression experiments were performed to identify dCORL-specific neurons. In these experiments, EcR-B1 protein expression was compared to dCORL mRNA expression revealing that they are not expressed in the …
- Tran, Nancy Lan, Newfeld, Stuart J, Capco, David G, et al.
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