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## ASU Electronic Theses and Dissertations

This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.

In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.

Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.

Date Range
2010 2019

## Recent Submissions

Semi-supervised learning (SSL) is sub-field of statistical machine learning that is useful for problems that involve having only a few labeled instances with predictor (X) and target (Y) information, and abundance of unlabeled instances that only have predictor (X) information. SSL harnesses the target information available in the limited labeled data, as well as the information in the abundant unlabeled data to build strong predictive models. However, not all the included information is useful. For example, some features may correspond to noise and including them will hurt the predictive model performance. Additionally, some instances may not be as relevant to …

Contributors
Gaw, Nathan, Li, Jing, Wu, Teresa, et al.
Created Date
2019

Image-based process monitoring has recently attracted increasing attention due to the advancement of the sensing technologies. However, existing process monitoring methods fail to fully utilize the spatial information of images due to their complex characteristics including the high dimensionality and complex spatial structures. Recent advancement of the unsupervised deep models such as a generative adversarial network (GAN) and generative adversarial autoencoder (AAE) has enabled to learn the complex spatial structures automatically. Inspired by this advancement, we propose an anomaly detection framework based on the AAE for unsupervised anomaly detection for images. AAE combines the power of GAN with the variational …

Contributors
YEH, HUAI-MING, Yan, Hao, Pan, Rong, et al.
Created Date
2019

With the development of computer and sensing technology, rich datasets have become available in many fields such as health care, manufacturing, transportation, just to name a few. Also, data come from multiple heterogeneous sources or modalities. This is a common phenomenon in health care systems. While multi-modality data fusion is a promising research area, there are several special challenges in health care applications. (1) The integration of biological and statistical model is a big challenge; (2) It is commonplace that data from various modalities is not available for every patient due to cost, accessibility, and other reasons. This results in …

Contributors
Liu, Xiaonan, Li, Jing, Wu, Teresa, et al.
Created Date
2019

Transfer learning is a sub-field of statistical modeling and machine learning. It refers to methods that integrate the knowledge of other domains (called source domains) and the data of the target domain in a mathematically rigorous and intelligent way, to develop a better model for the target domain than a model using the data of the target domain alone. While transfer learning is a promising approach in various application domains, my dissertation research focuses on the particular application in health care, including telemonitoring of Parkinson’s Disease (PD) and radiomics for glioblastoma. The first topic is a Mixed Effects Transfer Learning …

Contributors
Yoon, Hyunsoo, Li, Jing, Wu, Teresa, et al.
Created Date
2018

Mathematical modeling and decision-making within the healthcare industry have given means to quantitatively evaluate the impact of decisions into diagnosis, screening, and treatment of diseases. In this work, we look into a specific, yet very important disease, the Alzheimer. In the United States, Alzheimer’s Disease (AD) is the 6th leading cause of death. Diagnosis of AD cannot be confidently confirmed until after death. This has prompted the importance of early diagnosis of AD, based upon symptoms of cognitive decline. A symptom of early cognitive decline and indicator of AD is Mild Cognitive Impairment (MCI). In addition to this qualitative test, …

Contributors
Camarena, Raquel, Pedrielli, Giulia, Li, Jing, et al.
Created Date
2018

Technology advancements in diagnostic imaging, smart sensing, and health information systems have resulted in a data-rich environment in health care, which offers a great opportunity for Precision Medicine. The objective of my research is to develop data fusion and system informatics approaches for quality and performance improvement of health care. In my dissertation, I focus on three emerging problems in health care and develop novel statistical models and machine learning algorithms to tackle these problems from diagnosis to care to system-level decision-making. The first topic is diagnosis/subtyping of migraine to customize effective treatment to different subtypes of patients. Existing clinical …

Contributors
Si, Bing, Li, Jing, Montgomery, Douglas, et al.
Created Date
2018

Under different environmental conditions, the relationship between the design and operational variables of a system and the system’s performance is likely to vary and is difficult to be described by a single model. The environmental variables (e.g., temperature, humidity) are not controllable while the variables of the system (e.g. heating, cooling) are mostly controllable. This phenomenon has been widely seen in the areas of building energy management, mobile communication networks, and wind energy. To account for the complicated interaction between a system and the multivariate environment under which it operates, a Sparse Partitioned-Regression (SPR) model is proposed, which automatically searches …

Contributors
Ning, Shuluo, Li, Jing, Wu, Teresa, et al.
Created Date
2018

In healthcare facilities, health information systems (HISs) are used to serve different purposes. The radiology department adopts multiple HISs in managing their operations and patient care. In general, the HISs that touch radiology fall into two categories: tracking HISs and archive HISs. Electronic Health Records (EHR) is a typical tracking HIS, which tracks the care each patient receives at multiple encounters and facilities. Archive HISs are typically specialized databases to store large-size data collected as part of the patient care. A typical example of an archive HIS is the Picture Archive and Communication System (PACS), which provides economical storage and …

Contributors
Wang, Kun, Li, Jing, Wu, Teresa, et al.
Created Date
2018

Modern, advanced statistical tools from data mining and machine learning have become commonplace in molecular biology in large part because of the “big data” demands of various kinds of “-omics” (e.g., genomics, transcriptomics, metabolomics, etc.). However, in other fields of biology where empirical data sets are conventionally smaller, more traditional statistical methods of inference are still very effective and widely used. Nevertheless, with the decrease in cost of high-performance computing, these fields are starting to employ simulation models to generate insights into questions that have been elusive in the laboratory and field. Although these computational models allow for exquisite control …

Contributors
Seto, Christian, Pavlic, Theodore, Li, Jing, et al.
Created Date
2018

Major Depression, clinically called Major Depressive Disorder, is a mood disorder that affects about one eighth of population in US and is projected to be the second leading cause of disability in the world by the year 2020. Recent advances in biotechnology have enabled us to collect a great variety of data which could potentially offer us a deeper understanding of the disorder as well as advancing personalized medicine. This dissertation focuses on developing methods for three different aspects of predictive analytics related to the disorder: automatic diagnosis, prognosis, and prediction of long-term treatment outcome. The data used for each …

Contributors
Nie, Zhi, Ye, Jieping, He, Jingrui, et al.
Created Date
2017

Large-scale $\ell_1$-regularized loss minimization problems arise in high-dimensional applications such as compressed sensing and high-dimensional supervised learning, including classification and regression problems. In many applications, it remains challenging to apply the sparse learning model to large-scale problems that have massive data samples with high-dimensional features. One popular and promising strategy is to scaling up the optimization problem in parallel. Parallel solvers run multiple cores on a shared memory system or a distributed environment to speed up the computation, while the practical usage is limited by the huge dimension in the feature space and synchronization problems. In this dissertation, I carry …

Contributors
Li, Qingyang, Ye, Jieping, Xue, Guoliang, et al.
Created Date
2017

Imaging genetics is an emerging and promising technique that investigates how genetic variations affect brain development, structure, and function. By exploiting disorder-related neuroimaging phenotypes, this class of studies provides a novel direction to reveal and understand the complex genetic mechanisms. Oftentimes, imaging genetics studies are challenging due to the relatively small number of subjects but extremely high-dimensionality of both imaging data and genomic data. In this dissertation, I carry on my research on imaging genetics with particular focuses on two tasks---building predictive models between neuroimaging data and genomic data, and identifying disorder-related genetic risk factors through image-based biomarkers. To this …

Contributors
Yang, Tao, Ye, Jieping, Xue, Guoliang, et al.
Created Date
2017

Buildings consume nearly 50% of the total energy in the United States, which drives the need to develop high-fidelity models for building energy systems. Extensive methods and techniques have been developed, studied, and applied to building energy simulation and forecasting, while most of work have focused on developing dedicated modeling approach for generic buildings. In this study, an integrated computationally efficient and high-fidelity building energy modeling framework is proposed, with the concentration on developing a generalized modeling approach for various types of buildings. First, a number of data-driven simulation models are reviewed and assessed on various types of computationally expensive …

Contributors
Cui, Can, Wu, Teresa, Weir, Jeffery D., et al.
Created Date
2016

The presence of a rich set of embedded sensors on mobile devices has been fuelling various sensing applications regarding the activities of individuals and their surrounding environment, and these ubiquitous sensing-capable mobile devices are pushing the new paradigm of Mobile Crowd Sensing (MCS) from concept to reality. MCS aims to outsource sensing data collection to mobile users and it could revolutionize the traditional ways of sensing data collection and processing. In the meantime, cloud computing provides cloud-backed infrastructures for mobile devices to provision their capabilities with network access. With enormous computational and storage resources along with sufficient bandwidth, it functions …

Contributors
Wang, Zhijie, Wang, Zhijie, Xue, Guoliang, et al.
Created Date
2016

Transfer learning refers to statistical machine learning methods that integrate the knowledge of one domain (source domain) and the data of another domain (target domain) in an appropriate way, in order to develop a model for the target domain that is better than a model using the data of the target domain alone. Transfer learning emerged because classic machine learning, when used to model different domains, has to take on one of two mechanical approaches. That is, it will either assume the data distributions of the different domains to be the same and thereby developing one model that fits all, …

Contributors
Zou, Na, Li, Jing, Baydogan, Mustafa, et al.
Created Date
2015

Discriminative learning when training and test data belong to different distributions is a challenging and complex task. Often times we have very few or no labeled data from the test or target distribution, but we may have plenty of labeled data from one or multiple related sources with different distributions. Due to its capability of migrating knowledge from related domains, transfer learning has shown to be effective for cross-domain learning problems. In this dissertation, I carry out research along this direction with a particular focus on designing efficient and effective algorithms for BioImaging and Bilingual applications. Specifically, I propose deep …

Contributors
Sun, Qian, Ye, Jieping, Ye, Jieping, et al.
Created Date
2015

Recent advances in medical imaging technology have greatly enhanced imaging based diagnosis which requires computational effective and accurate algorithms to process the images (e.g., measure the objects) for quantitative assessment. In this dissertation, one type of imaging objects is of interest: small blobs. Example small blob objects are cells in histopathology images, small breast lesions in ultrasound images, glomeruli in kidney MR images etc. This problem is particularly challenging because the small blobs often have inhomogeneous intensity distribution and indistinct boundary against the background. This research develops a generalized four-phased system for small blob detections. The system includes (1) raw …

Contributors
Zhang, Min, Wu, Teresa, Li, Jing, et al.
Created Date
2015

Sparse learning is a powerful tool to generate models of high-dimensional data with high interpretability, and it has many important applications in areas such as bioinformatics, medical image processing, and computer vision. Recently, the a priori structural information has been shown to be powerful for improving the performance of sparse learning models. A graph is a fundamental way to represent structural information of features. This dissertation focuses on graph-based sparse learning. The first part of this dissertation aims to integrate a graph into sparse learning to improve the performance. Specifically, the problem of feature grouping and selection over a given …

Contributors
Yang, Sen, Ye, Jieping, Wonka, Peter, et al.
Created Date
2014

Data imbalance and data noise often coexist in real world datasets. Data imbalance affects the learning classifier by degrading the recognition power of the classifier on the minority class, while data noise affects the learning classifier by providing inaccurate information and thus misleads the classifier. Because of these differences, data imbalance and data noise have been treated separately in the data mining field. Yet, such approach ignores the mutual effects and as a result may lead to new problems. A desirable solution is to tackle these two issues jointly. Noting the complementary nature of generative and discriminative models, this research …

Contributors
He, Miao, Wu, Teresa, Li, Jing, et al.
Created Date
2014

Network traffic analysis by means of Quality of Service (QoS) is a popular research and development area among researchers for a long time. It is becoming even more relevant recently due to ever increasing use of the Internet and other public and private communication networks. Fast and precise QoS analysis is a vital task in mission-critical communication networks (MCCNs), where providing a certain level of QoS is essential for national security, safety or economic vitality. In this thesis, the details of all aspects of a comprehensive computational framework for QoS analysis in MCCNs are provided. There are three main QoS …

Contributors
Senturk, Muhammet Burhan, Li, Jing, Baydogan, Mustafa G, et al.
Created Date
2014

In a healthcare setting, the Sterile Processing Department (SPD) provides ancillary services to the Operating Room (OR), Emergency Room, Labor & Delivery, and off-site clinics. SPD's function is to reprocess reusable surgical instruments and return them to their home departments. The management of surgical instruments and medical devices can impact patient safety and hospital revenue. Any time instrumentation or devices are not available or are not fit for use, patient safety and revenue can be negatively impacted. One step of the instrument reprocessing cycle is sterilization. Steam sterilization is the sterilization method used for the majority of surgical instruments and …

Contributors
Weart, Gail, Runger, George, Li, Jing, et al.
Created Date
2014

A P-value based method is proposed for statistical monitoring of various types of profiles in phase II. The performance of the proposed method is evaluated by the average run length criterion under various shifts in the intercept, slope and error standard deviation of the model. In our proposed approach, P-values are computed at each level within a sample. If at least one of the P-values is less than a pre-specified significance level, the chart signals out-of-control. The primary advantage of our approach is that only one control chart is required to monitor several parameters simultaneously: the intercept, slope(s), and the …

Contributors
Adibi, Azadeh, Montgomery, Douglas, Borror, Connie, et al.
Created Date
2013

Hepatocellular carcinoma (HCC) is a malignant tumor and seventh most common cancer in human. Every year there is a significant rise in the number of patients suffering from HCC. Most clinical research has focused on HCC early detection so that there are high chances of patient's survival. Emerging advancements in functional and structural imaging techniques have provided the ability to detect microscopic changes in tumor micro environment and micro structure. The prime focus of this thesis is to validate the applicability of advanced imaging modality, Magnetic Resonance Elastography (MRE), for HCC diagnosis. The research was carried out on three HCC …

Contributors
Bansal, Gaurav, Wu, Teresa, Mitchell, Ross, et al.
Created Date
2013

Rapid advance in sensor and information technology has resulted in both spatially and temporally data-rich environment, which creates a pressing need for us to develop novel statistical methods and the associated computational tools to extract intelligent knowledge and informative patterns from these massive datasets. The statistical challenges for addressing these massive datasets lay in their complex structures, such as high-dimensionality, hierarchy, multi-modality, heterogeneity and data uncertainty. Besides the statistical challenges, the associated computational approaches are also considered essential in achieving efficiency, effectiveness, as well as the numerical stability in practice. On the other hand, some recent developments in statistics and …

Contributors
Huang, Shuai, Li, Jing, Li, Jing, et al.
Created Date
2012

The technology expansion seen in the last decade for genomics research has permitted the generation of large-scale data sources pertaining to molecular biological assays, genomics, proteomics, transcriptomics and other modern omics catalogs. New methods to analyze, integrate and visualize these data types are essential to unveil relevant disease mechanisms. Towards these objectives, this research focuses on data integration within two scenarios: (1) transcriptomic, proteomic and functional information and (2) real-time sensor-based measurements motivated by single-cell technology. To assess relationships between protein abundance, transcriptomic and functional data, a nonlinear model was explored at static and temporal levels. The successful integration of …

Contributors
Torres Garcia, Wandaliz, Meldrum, Deirdre R., Runger, George C., et al.
Created Date
2011

In today's global market, companies are facing unprecedented levels of uncertainties in supply, demand and in the economic environment. A critical issue for companies to survive increasing competition is to monitor the changing business environment and manage disturbances and changes in real time. In this dissertation, an integrated framework is proposed using simulation and online calibration methods to enable the adaptive management of large-scale complex supply chain systems. The design, implementation and verification of the integrated approach are studied in this dissertation. The research contributions are two-fold. First, this work enriches symbiotic simulation methodology by proposing a framework of simulation …

Contributors
Wang, Shanshan, Wu, Teresa, Fowler, John, et al.
Created Date
2010