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Timing performance is sensitive to fluctuations in time and motivation, thus interval timing and motivation are either inseparable or conflated processes. A behavioral systems model (e.g., Timberlake, 2000) of timing performance (Chapter 1) suggests that timing performance in externally-initiated (EI) procedures conflates behavioral modes differentially sensitive to motivation, but that response-initiated (RI) procedures potentially dissociate these behavioral modes. That is, timing performance in RI procedures is expected to not conflate these behavioral modes. According to the discriminative RI hypothesis, as initiating-responses become progressively discriminable from target responses, initiating-responses increasingly dissociate interval timing and motivation. Rats were trained in timing procedures …

Contributors

Daniels, Carter W, Sanabria, Federico, McClure, Samuel M., et al.

Created Date

2018

In recent years, the use of biologically based (neurological, neuropsychological, genetic) evidence in criminal trials as support for claims of mental impairments among offenders has increased in popularity. However, research on how exposure to those arguments affects jury decision-making remains unclear. Specifically, arguments rooted in biology sometimes mitigate and sometimes aggravate judgments of criminal responsibility for mentally ill offenders, and this discrepancy seems to stem from the specific conditions by which that disorder was acquired. The following study’s aim was to uncover the precise mechanism(s) behind this elusive effect. Utilizing a 2x2 between subjects experimental design, participants were presented with …

Contributors

Hunter, Shelby, Schweitzer, Nick, Neal, Tess, et al.

Created Date

2017

Latino youth have substantially higher rates of obesity and T2D than their white peers. The higher prevalence of obesity and T2D among Latino youth places them at greater risk for cognitive dysfunction, an urgent and serious health threat to the United States. Exercise has been the cornerstone to combat the negative effects of obesity, diabetes and recent research also supports this effects for preventing cognitive dysfunction. A wealth of evidence suggests that a mediating mechanism linking exercise with brain health is BDNF, a cognitive biomarker that increases in the brain with exercise. BDNF is the most abundant neurotrophic factor that …

Contributors

Barraza, Estela, Shaibi, Gabriel Q., Swan, Pamela, et al.

Created Date

2016

MicroRNAs are small, non-coding transcripts that post-transcriptionally regulate expression of multiple genes. Recently microRNAs have been linked to the etiology of neuropsychiatric disorders, including drug addiction. Following genome-wide sequence analyses, microRNA-495 (miR-495) was found to target several genes within the Knowledgebase of Addiction-Related Genes (KARG) database and to be highly expressed in the nucleus accumbens (NAc), a pivotal brain region involved in reward and motivation. The central hypothesis of this dissertation is that NAc miR-495 regulates drug abuse-related behavior by targeting several addiction-related genes (ARGs). I tested this hypothesis in two ways: 1) by examining the effects of viral-mediated miR-495 …

Contributors

Bastle, Ryan, Neisewander, Janet, Newbern, Jason, et al.

Created Date

2016

Theories of interval timing have largely focused on accounting for the aggregate properties of behavior engendered by periodic reinforcement, such as sigmoidal psychophysical functions and their scalar property. Many theories of timing also stipulate that timing and motivation are inseparable processes. Such a claim is challenged by fluctuations in and out of states of schedule control, making it unclear whether motivation directly affects states related to timing. The present paper seeks to advance our understanding of timing performance by analyzing and comparing the distribution of latencies and inter-response times (IRTs) of rats in two fixed-interval (FI) schedules of food reinforcement …

Contributors

Daniels, Carter Waymon, Sanabria, Federico, Brewer, Gene, et al.

Created Date

2015

Aging and the menopause transition are both intricately linked to cognitive changes during mid-life and beyond. Clinical literature suggests the age at menopause onset can differentially impact cognitive status later in life. Yet, little is known about the relationship between behavioral and brain changes that occur during the transitional stage into the post-menopausal state. Much of the pre-clinical work evaluating an animal model of menopause involves ovariectomy in rodents; however, ovariectomy results in an abrupt loss of circulating hormones and ovarian tissue, limiting the ability to evaluate gradual follicular depletion. The 4-vinylcyclohexene diepoxide (VCD) model simulates transitional menopause in rodents …

Contributors

Koebele, Stephanie Victoria, Bimonte-Nelson, Heather A, Aiken, Leona S, et al.

Created Date

2015

The advertising industry plays a crucial role in how ideals and norms are established in United States society. Recent work is revealing the negative impact advertisements can have on self-esteem and self-image, especially for women. Unrealistic body-types, often created through photo editing, continue to contribute to eating and emotional disorders. Such fabricated ideals hinder the progress of social and economic justice for women. This exploratory study investigates whether images of women in traditionally male-dominated roles can weaken sexist attitudes and whether less sexism and highly sexist groups differ in image processing. Participants who scored high or low on the Ambivalent …

Contributors

Ostendorf, Tasha, Swadener, Elizabeth, Arizona State University

Created Date

2015

Intermittent social defeat stress produces vulnerability to drugs of abuse, a phenomena known as cross-sensitization, which is proceeded by a corresponding upregulation of ventral tegmental area (VTA) mu-opioid receptors (MORs). Since VTA MORs are implicated in the expression of psychostimulant sensitization, they may also mediate social stress-induced vulnerability to drugs of abuse. Social stress and drugs of abuse increase mesolimbic brain-derived neurotrophic factor (BDNF) signaling with its receptor, tropomyosin-related kinase B (TrkB). These studies examined whether VTA MOR signaling is important for the behavioral and cellular consequences of social stress. First, the function of VTA MORs in the behavioral consequences …

Contributors

Johnston, Caitlin Elizabeth, Hammer, Ronald P., Nikulina, Ella M., et al.

Created Date

2015

This study explores the psychophysical and neural processes associated with the perception of sounds as either pleasant or aversive. The underlying psychophysical theory is based on auditory scene analysis, the process through which listeners parse auditory signals into individual acoustic sources. The first experiment tests and confirms that a self-rated pleasantness continuum reliably exists for 20 various stimuli (r = .48). In addition, the pleasantness continuum correlated with the physical acoustic characteristics of consonance/dissonance (r = .78), which can facilitate auditory parsing processes. The second experiment uses an fMRI block design to test blood oxygen level dependent (BOLD) changes elicited …

Contributors

Patten, Kristopher Jakob, McBeath, Michael K, Baxter, Leslie C, et al.

Created Date

2014

Patients with schizophrenia have impaired cognitive flexibility, as evidenced by behaviors of perseveration. Cognitive impairments may be due to dysregulation of glutamate and/or loss of neuronal plasticity in the medial prefrontal cortex (mPFC). The purpose of these studies was to examine the effects of mGluR5 positive allosteric modulators (PAMs) alone and in combination with the NMDAR antagonist MK-801, a pharmacological model of schizophrenia. An operant-based cognitive set-shifting task was utilized to assess cognitive flexibility, in vivo microdialysis procedures to measure extracellular glutamate levels in the mPFC, and diolistic labeling to assess the effects on dendritic spine density and morphology in …

Contributors

LaCrosse, Amber, Olive, Michael, Olive, Michael, et al.

Created Date

2014