ASU Electronic Theses and Dissertations
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Optimal design theory provides a general framework for the construction of experimental designs for categorical responses. For a binary response, where the possible result is one of two outcomes, the logistic regression model is widely used to relate a set of experimental factors with the probability of a positive (or negative) outcome. This research investigates and proposes alternative designs to alleviate the problem of separation in small-sample D-optimal designs for the logistic regression model. Separation causes the non-existence of maximum likelihood parameter estimates and presents a serious problem for model fitting purposes. First, it is shown that exact, multi-factor D-optimal …
- Park, Anson Robert, Montgomery, Douglas C, Mancenido, Michelle V, et al.
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