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ASU Electronic Theses and Dissertations


This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.

In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.

Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.


Resource Type
Status
  • Public
Date Range
2010 2019


Solid tumors advance from benign stage to a deadly metastatic state due to the complex interaction between cancer cells and tumor microenvironment (TME) including stromal cells and extracellular matrix (ECM). Multiple studies have demonstrated that ECM dysregulation is one of the critical hallmarks of cancer progression leading to formation of a desmoplastic microenvironment that participates in tumor progression. Cancer associated fibroblasts (CAFs) are the predominant stromal cell type that participates in desmoplasia by depositing matrix proteins and increasing ECM stiffness. Although the influence of matrix stiffness on enhanced tumorigenicity has been well studied, the biological understanding about the dynamic changes …

Contributors
Saini, Harpinder, Nikkhah, Mehdi, Ros, Robert, et al.
Created Date
2019

Peripheral Vascular Disease (PVD) is a debilitating chronic disease of the lower extremities particularly affecting older adults and diabetics. It results in reduction of the blood flow to peripheral tissue and sometimes causing tissue damage such that PVD patients suffer from pain in the lower legs, thigh and buttocks after activities. Electrical neurostimulation based on the "Gate Theory of Pain" is a known to way to reduce pain but current devices to do this are bulky and not well suited to implantation in peripheral tissues. There is also an increased risk associated with surgery which limits the use of these …

Contributors
Zong, Xi, Towe, Bruce, Kleim, Jeffrey, et al.
Created Date
2014

As the application of interactive media systems expands to address broader problems in health, education and creative practice, they fall within a higher dimensional space for which it is inherently more complex to design. In response to this need an emerging area of interactive system design, referred to as experiential media systems, applies hybrid knowledge synthesized across multiple disciplines to address challenges relevant to daily experience. Interactive neurorehabilitation (INR) aims to enhance functional movement therapy by integrating detailed motion capture with interactive feedback in a manner that facilitates engagement and sensorimotor learning for those who have suffered neurologic injury. While …

Contributors
Lehrer, Nicole, Rikakis, Thanassis, Rikakis, Thanassis, et al.
Created Date
2014

The purpose of this study is to examine and explore Hatha Yoga and how it relates to a practice consisting of singer-friendly yoga postures, how these postures may benefit the singer's mental and physical health, and how these techniques relate to designated research. The study also investigates yogic breathing techniques and how these exercises relate to selected research. Lastly, the paper examines how the voice student and professional singer may alleviate anxiety by introducing a practice of daily yogic mediation of mudra and mantra techniques, and how voice teachers may better understand and assist their students with stage performance anxiety. …

Contributors
Hutton, Christopher, Rogers, Rodney, Doan, Jerry, et al.
Created Date
2014

Mathematical models are important tools for addressing problems that exceed experimental capabilities. In this work, I present ordinary and partial differential equation (ODE, PDE) models for two problems: Vicodin abuse and impact cratering. The prescription opioid Vicodin is the nation's most widely prescribed pain reliever. The majority of Vicodin abusers are first introduced via prescription, distinguishing it from other drugs in which the most common path to abuse begins with experimentation. I develop and analyze two mathematical models of Vicodin use and abuse, considering only those patients with an initial Vicodin prescription. Through adjoint sensitivity analysis, I show that focusing …

Contributors
Caldwell, Wendy K, Wirkus, Stephen, Asphaug, Erik, et al.
Created Date
2019

With the growth of global population, the demand for sustainable infrastructure is significantly increasing. Substructures with appropriate materials are required to be built in or above soil that can support the massive volume of construction demand. However, increased structural requirements often require ground improvement to increase the soil capacity. Moreover, certain soils are prone to liquefaction during an earthquake, which results in significant structural damage and loss of lives. While various soil treatment methods have been developed in the past to improve the soil’s load carrying ability, most of these traditional treatment methods have been found either hazardous and may …

Contributors
Yang, Pu, Neithalath, Narayanan, Kavazanjian, Edward, et al.
Created Date
2018

DNA nanotechnology has been a rapidly growing research field in the recent decades, and there have been extensive efforts to construct various types of highly programmable and robust DNA nanostructures. Due to the advantage that DNA nanostructure can be used to organize biochemical molecules with precisely controlled spatial resolution, herein we used DNA nanostructure as a scaffold for biological applications. Targeted cell-cell interaction was reconstituted through a DNA scaffolded multivalent bispecific aptamer, which may lead to promising potentials in tumor therapeutics. In addition a synthetic vaccine was constructed using DNA nanostructure as a platform to assemble both model antigen and …

Contributors
Liu, Xiaowei, Liu, Yan, Chang, Yung, et al.
Created Date
2012

For a conventional quadcopter system with 4 planar rotors, flight times vary between 10 to 20 minutes depending on the weight of the quadcopter and the size of the battery used. In order to increase the flight time, either the weight of the quadcopter should be reduced or the battery size should be increased. Another way is to increase the efficiency of the propellers. Previous research shows that ducting a propeller can cause an increase of up to 94 % in the thrust produced by the rotor-duct system. This research focused on developing and testing a quadcopter having a centrally …

Contributors
Lal, Harsh, Artemiadis, Panagiotis, Lee, Hyunglae, et al.
Created Date
2019

Breast cancer cell invasion is a highly orchestrated process driven by a myriad of complex microenvironmental stimuli. These complexities make it difficult to isolate and assess the effects of specific parameters including matrix stiffness and tumor architecture on disease progression. In this regard, morphologically accurate tumor models are becoming instrumental to perform fundamental studies on cancer cell invasion within well-controlled conditions. In this study, the use of photocrosslinkable hydrogels and a novel, two-step photolithography technique was explored to microengineer a 3D breast tumor model. The microfabrication process presented herein enabled precise localization of the cells and creation of high stiffness …

Contributors
Sam, Feba, Nikkhah, Mehdi, Ros, Robert, et al.
Created Date
2015

Utilizing visual semiotics and performance theories as a backdrop to inform a discussion regarding entertainment education and community dialogue, this study explores a unique case of compassionate communication being enacted at the most crucial moment – facing a school shooter at the height of a critical juncture. Through narrative film techniques and dramatism, a recreation of the real-life event was re-framed and distilled into a documentary-style film to showcase to general audiences for the purpose of dialogue catalyzation and elicitation. The film acts as a provocative statement for the process of conducting a Civil Dialogue® with the viewing audience. Qualitative …

Contributors
Fisher, Rosalie, Margolis, Eric, Broome, Benjamin, et al.
Created Date
2019

Over the past three decades, particle image velocimetry (PIV) has been continuously growing to become an informative and robust experimental tool for fluid mechanics research. Compared to the early stage of PIV development, the dynamic range of PIV has been improved by about an order of magnitude (Adrian, 2005; Westerweel et al., 2013). Further improvement requires a breakthrough innovation, which constitutes the main motivation of this dissertation. N-pulse particle image velocimetry-accelerometry (N-pulse PIVA, where N>=3) is a promising technique to this regard. It employs bursts of N pulses to gain advantages in both spatial and temporal resolution. The performance improvement …

Contributors
Ding, Liuyang, Adrian, Ronald J, Frakes, David, et al.
Created Date
2018

The symphonies of Gustav Mahler (1860 - 1911) constitute an essential element of the orchestral repertory; they are therefore essential for young conductors to understand and for instrumentalists to play. Yet they are impractical in many school situations because they call for large orchestras. One solution to this problem is for the conductor to study the original, full version of the works as Mahler composed them, but to consider performing one of the reduced instrumentations now available. A smaller-scale version provides an opportunity for both the conductor and the instrumentalists to confront the challenges of performing Mahler's music and to …

Contributors
Kwon, Junghwan, Schildkret, David, Caslor, Jason, et al.
Created Date
2016

Some cyanobacteria, referred to as boring or euendolithic, are capable of excavating tunnels into calcareous substrates, both mineral and biogenic. The erosive activity of these cyanobacteria results in the destruction of coastal limestones and dead corals, the reworking of carbonate sands, and the cementation of microbialites. They thus link the biological and mineral parts of the global carbon cycle directly. They are also relevant for marine aquaculture as pests of mollusk populations. In spite of their importance, the mechanism by which these cyanobacteria bore remains unknown. In fact, boring by phototrophs is geochemically paradoxical, in that they should promote precipitation …

Contributors
Ramírez-Reinat, Edgardo Luis, Garcia-Pichel, Ferran, Chandler, Douglas, et al.
Created Date
2010

Two different techniques utilizing vocalization in clarinet performance were examined through a research study in which one subject (the author) played several tasks utilizing each technique with different played pitches, vocalized pitches, and dynamic levels for each task. The first technique was singing while playing, which is also sometimes referred to as growling. This technique is produced by engaging the vocal folds during regular clarinet performance to create a second vocalized pitch that resonates in the oral cavity and exits through the mouthpiece as part of the same air stream as that used by the vibrating reed. The second technique …

Contributors
Ruth, Jeremy Larkham, Gardner, Joshua T, Spring, Robert S, et al.
Created Date
2019

In this work, the hydrodynamics of Suction Stabilization is studied. Suction stabilization was found to stabilize floating platforms/floats in a much better way as compared to the conventional methods. This was achieved by an effective increment in the metacentric height due to the Inverse Slack Tank (IST) effect. The study involves the analysis of the existing designs and optimizing its performance. This research investigates the stability of such floats and the hydrodynamic forces acting on the same for offshore applications, such as wind turbines. A simple mathematical model for the condition of parametric resonance is developed and the results are …

Contributors
Cherangara Subramanian, Susheelkumar, Redkar, Sangram, Rajadas, John, et al.
Created Date
2014

I am interested in performance that includes multiple artistic media. I am looking for a way to communicate with other artists that can clearly express the meaning of an artistic gesture that they can interpret for their medium. I wish to make transmedia performance art with a meaning that is clear to an audience. That meaning can be abstract. Sometimes we call art "abstract" to imply that it has no perceivable meaning. However, everything has meaning. Even if a piece of art does not have narrative meaning, we can still perceive a structure. That is thanks to our imagination. Imagination …

Contributors
Levy, Luis Alejandro, Hackbarth, Glenn, Hackbarth, Glenn, et al.
Created Date
2014

Several contemporary clarinet works use Chinese folk music elements from different regions in new compositions to entice listener's and performer's appreciation of Chinese culture. However, to date, limited academic research on this topic exists. This research paper introduces six contemporary clarinet works by six Chinese composers: Qigang Chen's Morning Song, Yan Wang's Mu ma zhi ge (The Song of Grazing Horses), An-lun Huang's Capriccio for Clarinet and Strings Op. 41, Bijing Hu's The Sound of Pamir Clarinet Concerto, Mei-Mi Lan's Concerto for Clarinet and String Orchestra with Harp and Percussion, and Yu-Hui Chang's Three Fantasias for Solo Clarinet in B-flat. …

Contributors
Feng, Chiao-Ting, Spring, Robert, Gardner, Joshua, et al.
Created Date
2013

The remarkable conservation of molecular and intra-/inter-cellular pathways underpinning the fundamental aspects of sugar partitioning in two evolutionarily divergent organisms – a non-vascular moss Physcomitrella patens and a vascular cereal crop Oryza sativa (rice) – forms the basis of this manuscript. Much of our current knowledge pertaining to sugar partitioning in plants mainly comes from studies in thale cress, Arabidopsis thaliana, but how photosynthetic sugar is loaded into the phloem in a crop as important as rice is still debated. Even less is known about the mechanistic aspects of sugar movement in mosses. In plants, sugar either moves passively via …

Contributors
Regmi, Kamesh Chandra, Gaxiola, Roberto A, Wojciechowski, Martin F, et al.
Created Date
2016

According to the World Health Organization, cancer is one of the leading causes of death around the world. Although early diagnostics using biomarkers and improved treatments with targeted therapy have reduced the rate of cancer related mortalities, there remain many unknowns regarding the contributions of the tumor microenvironment to cancer progression and therapeutic resistance. The tumor microenvironment plays a significant role by manipulating the progression of cancer cells through biochemical and biophysical signals from the surrounding stromal cells along with the extracellular matrix. As such, there is a critical need to understand how the tumor microenvironment influences the molecular mechanisms …

Contributors
Truong, Danh, Nikkhah, Mehdi, LaBaer, Joshua, et al.
Created Date
2018

Optical Fibers coupled to laser light sources, and Light Emitting Diodes are the two classes of technologies used for optogenetic experiments. Arizona State University's Flexible Display Center fabricates novel flexible Organic Light Emitting Diodes(OLEDs). These OLEDs have the capability of being monolithically fabricated over flexible, transparent plastic substrates and having power efficient ways of addressing high density arrays of LEDs. This thesis critically evaluates the technology by identifying the key advantages, current limitations and experimentally assessing the technology in in-vivo and in-vitro animal models. For in-vivo testing, the emitted light from a flat OLED panel was directly used to stimulate …

Contributors
Shah, Ankur Rajiv, Muthuswamy, Jitendran, Greger, Bradley, et al.
Created Date
2015

Volumetric cell imaging using 3D optical Computed Tomography (cell CT) is advantageous for identification and characterization of cancer cells. Many diseases arise from genomic changes, some of which are manifest at the cellular level in cytostructural and protein expression (functional) features which can be resolved, captured and quantified in 3D far more sensitively and specifically than in traditional 2D microscopy. Live single cells were rotated about an axis perpendicular to the optical axis to facilitate data acquisition for functional live cell CT imaging. The goal of this thesis research was to optimize and characterize the microvortex rotation chip. Initial efforts …

Contributors
Shetty, Rishabh M., Meldrum, Deirdre R, Johnson, Roger H, et al.
Created Date
2013

Single cell phenotypic heterogeneity studies reveal more information about the pathogenesis process than conventional bulk methods. Furthermore, investigation of the individual cellular response mechanism during rapid environmental changes can only be achieved at single cell level. By enabling the study of cellular morphology, a single cell three-dimensional (3D) imaging system can be used to diagnose fatal diseases, such as cancer, at an early stage. One proven method, CellCT, accomplishes 3D imaging by rotating a single cell around a fixed axis. However, some existing cell rotating mechanisms require either intricate microfabrication, and some fail to provide a suitable environment for living …

Contributors
Zhang, Wenjie, Frakes, David, Meldrum, Deirdre, et al.
Created Date
2011

Obtaining local electrochemical (EC) information is extremely important for understanding basic surface reactions, and for many applications. Scanning electrochemical microscopy (SECM) can obtain local EC information by scanning a microelectrode across the surface. Although powerful, SECM is slow, the scanning microelectrode may perturb reaction and the measured signal decreases with the size of microelectrode. This thesis demonstrates a new imaging technique based on a principle that is completely different from the conventional EC detection technologies. The technique, referred to as plasmonic-based electrochemical imaging (PECI), images local EC current (both faradaic and non-faradaic) without using a scanning microelectrode. Because PECI response …

Contributors
Shan, Xiaonan, Tao, Nongjian, Chae, Junseok, et al.
Created Date
2011

Rapid expansion of dense beds of fine, spherical particles subjected to rapid depressurization is studied in a vertical shock tube. As the particle bed is unloaded, a high-speed video camera captures the dramatic evolution of the particle bed structure. Pressure transducers are used to measure the dynamic pressure changes during the particle bed expansion process. Image processing, signal processing, and Particle Image Velocimetry techniques, are used to examine the relationships between particle size, initial bed height, bed expansion rate, and gas velocities. The gas-particle interface and the particle bed as a whole expand and evolve in stages. First, the bed …

Contributors
Zunino, Heather, Adrian, Ronald J, Clarke, Amanda, et al.
Created Date
2019
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Virtual Reality (hereafter VR) and Mixed Reality (hereafter MR) have opened a new line of applications and possibilities. Amidst a vast network of potential applications, little research has been done to provide real time collaboration capability between users of VR and MR. The idea of this thesis study is to develop and test a real time collaboration system between VR and MR. The system works similar to a Google document where two or more users can see what others are doing i.e. writing, modifying, viewing, etc. Similarly, the system developed during this study will enable users in VR and MR …

Contributors
Seth, Nayan Sateesh, Nelson, Brian, Walker, Erin, et al.
Created Date
2017

As digital technology promises immediacy and interactivity in communication, sight and sound in motion graphics has expanded the range of design possibilities in advertising, social networking, and telecommunication beyond the visual realm. The experience of seeing has been greatly enriched by sound as visual solutions become dynamic and multi-dimensional. The ability to record and transfer sight and sound with new media has granted the designer more control in manipulating a viewer's experience of time and space. This control allows time-based form to become the foundation that establishes many interactive, multisensory and interdisciplinary applications. Is conventional design theory for print media …

Contributors
Cheung, Hoi Yan Patrick, Giard, Jacques, Sanft, Alfred C, et al.
Created Date
2011

Nanocrystalline (nc) thin films exhibit a wide range of enhanced mechanical properties compared to their coarse-grained counterparts. Furthermore, the mechanical behavior and microstructure of nc films is intimately related. Thus, precise control of the size, aspect ratio and spatial distribution of grains can enable the synthesis of thin films with exceptional mechanical properties. However, conventional bottom-up techniques for synthesizing thin films are incapable of achieving the microstructural control required to explicitly tune their properties. This dissertation focuses on developing a novel technique to synthesize metallic alloy thin films with precisely controlled microstructures and subsequently characterizing their mechanical properties using in …

Contributors
Sarkar, Rohit, Rajagopalan, Jagannathan, Peralta, Pedro, et al.
Created Date
2017

The study of artist transcriptions is an effective vehicle for assimilating the language and style of jazz. Pairing transcriptions with historical context provides further insight into the back story of the artists' life and method. Innovators are often the subject of published studies of this kind, but transcriptions of plunger-mute master Al Grey have been overlooked. This document fills that void, combining historical context with thirteen transcriptions of Grey's trombone features and improvisations. Selection of transcribed materials was based on an examination of historically significant solos in Al Grey's fifty-five-year career. The results are a series of open-horn and plunger …

Contributors
Hopkins, Charles, Pilafian, Sam, Stauffer, Sandra, et al.
Created Date
2011

This research examines lateral separation zones and sand bar slope stability using two methods: a parallelized turbulence resolving model and full-scale laboratory experiments. Lateral flow separation occurs in rivers where banks exhibit strong curvature, for instance canyon rivers, sharp meanders and river confluences. In the Colorado River, downstream Glen Canyon Dam, lateral separation zones are the principal storage of sandbars. Maximum ramp rates have been imposed to Glen Canyon Dam operation to minimize mass loss of sandbars. Assessment of the effect of restricting maximum ramp rates in bar stability is conducted using multiple laboratory experiments. Results reveal that steep sandbar …

Contributors
ALVAREZ, LAURA V., Schmeeckle, Mark W., Dorn, Ronald I., et al.
Created Date
2015

Megafauna species worldwide have undergone dramatic declines since the end of the Pleistocene, twelve thousand years ago. In response, there have been numerous calls to increase conservation attention to these ecologically important species. However, introduced megafauna continue to be treated as pests. This thesis evaluates the extent of this conservation paradox in relation to changing megafauna diversity from the Pleistocene to the Anthropocene and finds that introductions have provided refuge for a substantial number threatened and endangered megafaunal species and has restored generic diversity levels per continent to levels closer to the Pleistocene than the Holocene. Furthermore, this thesis describes …

Contributors
Lundgren, Erick, Stromberg, Juliet, Wu, Jianguo, et al.
Created Date
2017

Microfluidics is the study of fluid flow at very small scales (micro -- one millionth of a meter) and is prevalent in many areas of science and engineering. Typical applications include lab-on-a-chip devices, microfluidic fuel cells, and DNA separation technologies. Many of these microfluidic devices rely on micron-resolution velocimetry measurements to improve microchannel design and characterize existing devices. Methods such as micro particle imaging velocimetry (microPIV) and micro particle tracking velocimetry (microPTV) are mature and established methods for characterization of steady 2D flow fields. Increasingly complex microdevices require techniques that measure unsteady and/or three dimensional velocity fields. This dissertation presents …

Contributors
Klein, Steven Adam, Posner, Jonathan D, Adrian, Ronald, et al.
Created Date
2011

This research paper recounts the work done in founding an opera company and putting on its inaugural show. It also provides some of the insights acquired during the process, which may be helpful for other future opera producers in creating a framework and guideposts for starting their own companies. The paper consists of two main sections followed by several short appendices. The first section methodically reconstructs the process by which Windy City Opera's La Bohème was brought to the stage. It covers the background experiences that prompted the author to found her own company, the research and decisions involved, and …

Contributors
O'Shaughnessy, Catherine, Dreyfoos, Dale, Schildkret, David, et al.
Created Date
2016