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Immunosignature of Alzheimer's Disease

Abstract The goal of this thesis is to test whether Alzheimer's disease (AD) is associated with distinctive humoral immune changes that can be detected in plasma and tracked across time. This is relevant because AD is the principal cause of dementia, and yet, no specific diagnostic tests are universally employed in clinical practice to predict, diagnose or monitor disease progression. In particular, I describe herein a proteomic platform developed at the Center for Innovations in Medicine (CIM) consisting of a slide with 10.000 random-sequence peptides printed on its surface, which is used as the solid phase of an immunoassay where antibodies of interest are allowed to react and subsequently detected with a labeled secondary antibody. The patter... (more)
Created Date 2011
Contributor Restrepo Jimenez, Lucas (Author) / Johnston, Stephen A (Advisor) / Chang, Yung (Committee member) / Reiman, Eric (Committee member) / Sierks, Michael (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Neurosciences / Alzheimer's Disease / Antibodies / Diagnosis / Immunology / Microarray / Proteomics
Type Doctoral Dissertation
Extent 119 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Molecular and Cellular Biology 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis