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Replication of DNA Tetrahedron and Higher-order Self-assembly of DNA Origami

Abstract Deoxyribonucleic acid (DNA) has been treated as excellent building material for nanoscale construction because of its unique structural features. Its ability to self-assemble into predictable and addressable nanostructures distinguishes it from other materials. A large variety of DNA nanostructures have been constructed, providing scaffolds with nanometer precision to organize functional molecules. This dissertation focuses on developing biologically replicating DNA nanostructures to explore their biocompatibility for potential functions in cells, as well as studying the molecular behaviors of DNA origami tiles in higher-order self-assembly for constructing DNA nanostructures with large size and complexity. Presented here are a series of st... (more)
Created Date 2012
Contributor Li, Zhe (Author) / Yan, Hao (Advisor) / Liu, Yan (Advisor) / Seo, Dong-Kyun (Committee member) / Wachter, Rebekka (Committee member) / Arizona State University (Publisher)
Subject Nanotechnology / DNA self-assembly
Type Doctoral Dissertation
Extent 210 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Biochemistry 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis