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A Simultaneous Physically and Chemically Gelling Polymer System for Endovascular Embolization of Cerebral Aneurysms


Abstract Current treatment methods for cerebral aneurysms are providing life-saving measures for patients suffering from these blood vessel wall protrusions; however, the drawbacks present unfortunate circumstances in the invasive procedure or with efficient occlusion of the aneurysms. With the advancement of medical devices, liquid-to-solid gelling materials that could be delivered endovascularly have gained interest. The development of these systems stems from the need to circumvent surgical methods and the requirement for improved occlusion of aneurysms to prevent recanalization and potential complications. The work presented herein reports on a liquid-to-solid gelling material, which undergoes gelation via dual mechanisms. Using a temperature-re... (more)
Created Date 2012
Contributor Bearat, Hanin H. (Author) / Vernon, Brent L (Advisor) / Frakes, David (Committee member) / Massia, Stephen (Committee member) / Pauken, Christine (Committee member) / Preul, Mark (Committee member) / Solis, Francisco (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Aneurysms / Chemical cross-link / Embolic agent / Hydrogel / Polymer poly(N-isopropylacrylamide) / Thermosensitive
Type Doctoral Dissertation
Extent 242 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Bioengineering 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis