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On the Dynamics of Epileptic Spikes and Focus Localization in Temporal Lobe Epilepsy


Abstract Interictal spikes, together with seizures, have been recognized as the two hallmarks of epilepsy, a brain disorder that 1% of the world's population suffers from. Even though the presence of spikes in brain's electromagnetic activity has diagnostic value, their dynamics are still elusive. It was an objective of this dissertation to formulate a mathematical framework within which the dynamics of interictal spikes could be thoroughly investigated. A new epileptic spike detection algorithm was developed by employing data adaptive morphological filters. The performance of the spike detection algorithm was favorably compared with others in the literature. A novel spike spatial synchronization measure was developed and tested on coupled s... (more)
Created Date 2012
Contributor Krishnan, Balu (Author) / Iasemidis, Leonidas (Advisor) / Tsakalis, Kostantinos (Committee member) / Spanias, Andreas (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Subject Electrical engineering / Biomedical engineering / Neurosciences / Epilepsy / Focus Localization / Interictal Spikes / Resetting of Brain Dynamics / Spike Detection / Synchronization
Type Doctoral Dissertation
Extent 133 pages
Language English
Copyright
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Note Ph.D. Electrical Engineering 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis