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A Mathematical Model of Dopamine Neurotransmission


Abstract Dopamine (DA) is a neurotransmitter involved in attention, goal oriented behavior, movement, reward learning, and short term and working memory. For the past four decades, mathematical and computational modeling approaches have been useful in DA research, and although every modeling approach has limitations, a model is an efficient way to generate and explore hypotheses. This work develops a model of DA dynamics in a representative, single DA neuron by integrating previous experimental, theoretical and computational research. The model consists of three compartments: the cytosol, the vesicles, and the extracellular space and forms the basis of a new mathematical paradigm for examining the dynamics of DA synthesis, storage, release and reupt... (more)
Created Date 2012
Contributor Tello-Bravo, David (Author) / Crook, Sharon M (Advisor) / Greenwood, Priscilla E (Advisor) / Baer, Steven M (Committee member) / Castaneda, Edward (Committee member) / Castillo-Chavez, Carlos (Committee member) / Arizona State University (Publisher)
Subject Applied mathematics / Neurosciences / Applied Mathematics / Cocaine / Dopamine / Dopamine Transporter / Extracellular Space / Inhibition
Type Doctoral Dissertation
Extent 120 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Applied Mathematics for the Life and Social Sciences 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis