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Study of Edwardsiella ictaluri Conserved Genes Towards the Development of an Attenuated Recombinant Vaccine for Fish Host

Abstract Teleosts have the most primitive adaptive immune system. However, in terms of functionality the teleost immune system is similar to birds and mammals. On the other hand, enteric bacterial pathogens of mammals and birds present conserved regulatory mechanisms that control virulence factors. In this context, deletion of conserved genes that control virulence factors have been successfully used as measure to construct live attenuated bacterial vaccines for mammals and birds. Here, I hypothesize that evolutionary conserved genes, which control virulence factors or are essential for bacterial physiology in Enterobacteriaceae, could be used as universal tools to design live attenuated recombinant bacterial vaccines from fish to mammals. The evolu... (more)
Created Date 2012
Contributor Santander, Javier (Author) / Curtiss, Roy Iii (Advisor) / Chandler, Douglas (Committee member) / Chang, Yung (Committee member) / Shi, Yixin (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Animal diseases / Molecular biology / bacterial pathogenesis / catfish / Edwardsiella / Recombinant Vaccine
Type Doctoral Dissertation
Extent 206 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Microbiology 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis