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Characterization of Acetylcholine-Mediated Vasodilation in Mourning Dove Arteries Under Normoglycemic and Hyperglycemic Conditions


Abstract Birds have plasma glucose levels that are 1.5-2 times greater than mammals of similar body mass in addition to higher free fatty acid concentrations, both of which would typically impair endothelium-dependent vasodilation if observed in mammals. Endothelium-dependent vasodilation can be stimulated in mammals through the use of acetylcholine (ACh), which primarily acts through nitric oxide (NO) and cyclooxygenase (COX)-mediated pathways, with varying reliance on endothelial-derived hyperpolarizing factors (EDHFs). Very few studies have been conducted on small resistance systemic arteries from birds. The hypothesis was that because birds have naturally high glucose and free fatty acid concentrations, ACh-induced vasodilation of isolated arter... (more)
Created Date 2012
Contributor Jarrett, Catherine Lee (Author) / Sweazea, Karen L (Advisor) / Johnston, Carol (Committee member) / Gaesser, Glenn (Committee member) / Arizona State University (Publisher)
Subject Physiology / Nutrition / acetylcholine / artery / avian / hyperglycemia / oxidative stress / vasodilation
Type Masters Thesis
Extent 83 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Nutrition 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis