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From Plasma Peptide to Phenotype: The Emerging Role of Quiescin Sulfhydryl Oxidase 1 in Tumor Cell Biology.


Abstract Cancer is a disease that affects millions of people worldwide each year. The metastatic progression of cancer is the number one reason for cancer related deaths. Cancer preventions rely on the early identification of tumor cells as well as a detailed understanding of cancer as a whole. Identifying proteins specific to tumor cells provide an opportunity to develop noninvasive clinical tests and further our understanding of tumor biology. Using liquid chromatography-mass spectrometry (LC-MS/MS) a short peptide was identified in pancreatic cancer patient plasma that was not found in normal samples, and mapped back to QSOX1 protein. Immunohistochemistry was performed probing for QSOX1 in tumor tissue and discovered that QSOX1 is highly over-exp... (more)
Created Date 2012
Contributor Katchman, Benjamin (Author) / Lake, Douglas F. (Advisor) / Rawls, Jeffery A (Committee member) / Miller, Laurence J (Committee member) / Chang, Yung (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Breast Cancer / Invasion / Matrix Metalloproteinases / Metastasis / Pancreatic Cancer / QSOX1
Type Doctoral Dissertation
Extent 121 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Molecular and Cellular Biology 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis