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Diffusion-Weighted MR Imaging: Behaviors of Phenomenological Models and Enhanced PROPELLER Data Acquisition


Abstract The aim of this study was to investigate the microstructural sensitivity of the statistical distribution and diffusion kurtosis (DKI) models of non-monoexponential signal attenuation in the brain using diffusion-weighted MRI (DWI). We first developed a simulation of 2-D water diffusion inside simulated tissue consisting of semi-permeable cells and a variable cell size. We simulated a DWI acquisition using a pulsed gradient spin echo (PGSE) pulse sequence, and fitted the models to the simulated DWI signals using b-values up to 2500 s/mm2. For comparison, we calculated the apparent diffusion coefficient (ADC) of the monoexponential model (b-value = 1000 s/mm2). In separate experiments, we varied the cell size (5-10-15 μ), cell volume f... (more)
Created Date 2012
Contributor Lee, Chu-Yu (Author) / Debbins, Josef P (Advisor) / Bennett, Kevin M (Advisor) / Karam, Lina (Committee member) / Pipe, James G (Committee member) / Arizona State University (Publisher)
Subject Engineering
Type Doctoral Dissertation
Extent 156 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Electrical Engineering 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis