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Age Related Changes in Cognition and Brain: A Focus on Progestogens

Abstract Cognitive function declines with normal age and disease states, such as Alzheimer's disease (AD). Loss of ovarian hormones at menopause has been shown to exacerbate age-related memory decline and may be related to the increased risk of AD in women versus men. Some studies show that hormone therapy (HT) can have beneficial effects on cognition in normal aging and AD, but increasing evidence suggests that the most commonly used HT formulation is not ideal. Work in this dissertation used the surgically menopausal rat to evaluate the cognitive effects and mechanisms of progestogens proscribed to women. I also translated these questions to the clinic, evaluating whether history of HT use impacts hippocampal and entorhinal cortex volumes asse... (more)
Created Date 2012
Contributor Braden, Brittany Blair (Author) / Bimonte-Nelson, Heather A (Advisor) / Neisewander, Janet L (Committee member) / Conrad, Cheryl D (Committee member) / Baxter, Leslie C (Committee member) / Arizona State University (Publisher)
Subject Psychology / Psychobiology / Behavioral sciences / Aging / GABA / Hormones / Memory / Menopause / Progesterone
Type Doctoral Dissertation
Extent 324 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Psychology 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis