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High Serum Androstenedione Levels Correlate With Impaired Memory In The Surgically Menopausal Rat: A Replication And New Findings


Abstract After natural menopause in women, androstenedione becomes the primary hormone secreted by the residual follicle deplete ovaries. Two independent studies, in rodents that had undergone ovarian follicular depletion, found that higher serum androstenedione levels correlated with increased working memory errors. This led to the hypothesis that androstenedione impairs memory. The current study directly tested this hypothesis, examining the cognitive effects of androstenedione administration in a rodent model. Middle-aged ovariectomized rats received vehicle or one of two doses of androstenedione (4 or 8 mg/kg daily). Rats were tested on a spatial working and reference memory maze battery including the water radial arm maze, Morris maze, and dela... (more)
Created Date 2012
Contributor Camp, Bryan Walter (Author) / Bimonte-Nelson, Heather A (Advisor) / Olive, Michael F (Committee member) / Conrad, Cheryl D (Committee member) / Arizona State University (Publisher)
Subject Psychology / Neurosciences / aging / androgen / hormone / learning / memory / menopause
Type Masters Thesis
Extent 57 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.A. Psychology 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis