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Synthesis Of Halo Alkyl And Alkenyl Ortho-Carboxy Aryls And Bromo Nitro Lactones As Inhibitors Of Protein Tyrosine Phosphatases And Cancer Cell Growth


Abstract Changes to a cell's DNA can result in cancer, which is permanently sustained cellular proliferation. When malfunctioning genes, oncogenes, were verified to be of human origin in the 1970s, drugs were designed to target their encoded, abnormal enzymes. Tyrosine kinases have been established as an oft-modified oncogene enzyme family, but the protein tyrosine phosphatases (PTPs) were not investigated as thoroughly. PTPs have gradually been established as relevant enzymes that work in tandem with tyrosine kinases in cell signaling and are not just "house-keeping" enzymes. Some PTPs are thought to initiate tumorigenesis, and others may play a complementary role after the onset of cancer by extending the duration of cellular signals... (more)
Created Date 2012
Contributor Fadgen, Casey (Author) / Rose, Seth D (Advisor) / Francisco, Wilson (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Organic chemistry
Type Doctoral Dissertation
Extent 154 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Chemistry 2012
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis