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Cellular Mechanisms Underlying the Effects of Repeated D2-like Agonist Treatment on Prepulse Inhibition


Abstract Patients with schizophrenia have deficits in sensorimotor gating, the ability to gate out irrelevant stimuli in order to attend to relevant stimuli. Prepulse inhibition (PPI) of the startle response is a reliable and valid model of sensorimotor gating across species. Repeated D2-like agonist treatment alleviates prior PPI deficits in rats, termed a PPI recovery, and is observable 28 days after treatment. The aim of the current project is to illuminate the underlying mechanism for this persistent change of behavior and determine the clinical relevance of repeated D2-like agonist treatment. Our results revealed a significant increase in Delta FosB, a transcription factor, in the nucleus accumbens (NAc) 10 days after repeated D2-like agonist t... (more)
Created Date 2013
Contributor Maple, Amanda Marie (Author) / Hammer, Ronald P (Advisor) / Olive, Michael F (Committee member) / Gallitano, Amelia L (Committee member) / Conrad, Cheryl D (Committee member) / Nikulina, Ella M (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Pharmacology / Behavioral sciences / D2 receptor agonist / Delta FosB / dopamine / nucleus accumbens / prepulse inhibition / schizophrenia
Type Doctoral Dissertation
Extent 166 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Psychology 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis