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Identification of Novel Genetic Mechanisms Required for Bacterial Resistance to Antimicrobial Peptides

Abstract The study of bacterial resistance to antimicrobial peptides (AMPs) is a significant area of interest as these peptides have the potential to be developed into alternative drug therapies to combat microbial pathogens. AMPs represent a class of host-mediated factors that function to prevent microbial infection of their host and serve as a first line of defense. To date, over 1,000 AMPs of various natures have been predicted or experimentally characterized. Their potent bactericidal activities and broad-based target repertoire make them a promising next-generation pharmaceutical therapy to combat bacterial pathogens. It is important to understand the molecular mechanisms, both genetic and physiological, that bacteria employ to circumvent the b... (more)
Created Date 2013
Contributor Griffin, Natasha Monette (Author) / Shi, Yixin (Advisor) / Clark-Curtiss, Josephine (Committee member) / Misra, Rajeev (Committee member) / Nickerson, Cheryl (Committee member) / Stout, Valerie (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Genetics / Molecular biology / antimicrobial peptides / CpxR/A / Escherichia coli / resistance / screen
Type Doctoral Dissertation
Extent 168 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Molecular and Cellular Biology 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis