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Selenium Supplementation and Cardiovascular Outcome Markers in Hemodialysis Patients: A Randomized, Controlled Trial


Abstract Background Hemodialysis (HD) patients elicit an oxidant-antioxidant imbalance in addition to a selenium deficiency, possibly contributing to cardiovascular disease (CVD) mortality. Objective To evaluate the effect of selenium supplementation on CVD outcomes and antioxidant status in HD patients. Design A randomized controlled intervention trial conducted from October 2012 to January 2013. Participants/setting The study included 27 maintenance HD patients (61.1+17.5y, 14M, 13F) receiving HD in the greater Phoenix, AZ area. Intervention Patients received one of three treatments daily: 2 Brazil nuts, (5g, 181µg/day of selenium as selenomethionine [predicted]), 1 tablet of selenium (200µg/day of selenium as selenomethionine), or control (3 gumm... (more)
Created Date 2013
Contributor Sussman, Elizabeth Jessica (Author) / Johnston, Carol S (Advisor) / Boren, Kenneth (Committee member) / Mayol-Kreiser, Sandra (Committee member) / Sweazea, Karen (Committee member) / Vaughan, Linda (Committee member) / Arizona State University (Publisher)
Subject Nutrition / brain natriuretic peptide / glutathione peroxidase / hemodialysis / nutrition / selenium / vitamin c
Type Doctoral Dissertation
Extent 85 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Nutrition 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis