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The Effects of Maternal Separation on Adult Methamphetamine Self-Administration Extinction, Reinstatement, and MeCP2 Immunoreactivity in the Nucleus Accumbens

Abstract The maternal separation (MS) paradigm is an animal model of early life stress. Animals subjected to MS during the first two weeks of life display altered behavioral and neuroendocrinological stress responses as adults. MS also produces altered responsiveness to and self-administration (SA) of various drugs of abuse including cocaine, ethanol, opioids, and amphetamine. Methamphetamine (METH) causes great harm to both the individual user and to society; yet, no studies have examined the effects of MS on METH SA. This study was performed to examine the effects of MS on the acquisition of METH SA, extinction, and reinstatement of METH-seeking behavior in adulthood. Given the known influence of early life stress and drug exposure on epigenetic p... (more)
Created Date 2013
Contributor Lewis, Candace (Author) / Olive, Micheal F (Advisor) / Conrad, Cheryl (Committee member) / Neisewander, Janet (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Behavioral sciences / Early life stress / epigenetics / mecp2 / methamphetamine / self administration
Type Masters Thesis
Extent 38 pages
Language English
Reuse Permissions All Rights Reserved
Note M.A. Psychology 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis