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MRI Visualization and Mathematical Modeling of Local Drug Delivery

Abstract Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo. In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery is performed to visualize and quantify the time resolved distribution of MRI contrast agents. I find it is possible to visualize contrast agent distributions in near real time from local delivery vehicles using MRI. Three dimensional T1 maps are processed to produce in vivo concentration maps of contrast agent for individual animal model... (more)
Created Date 2013
Contributor Giers, Morgan Boresi (Author) / Caplan, Michael R (Advisor) / Massia, Stephen P (Committee member) / Frakes, David (Committee member) / Mclaren, Alex C (Committee member) / Vernon, Brent L (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Mathematics / Surgery / Drug Delivery / Image Processing / Infection / MRI / Orthopaedics / Transport
Type Doctoral Dissertation
Extent 179 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Bioengineering 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis