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Lead Identification, Optimization and Characterization of Novel Cancer Treatment Strategies Using Repositioned Drugs

Abstract Cancer is the second leading cause of death in the United States and novel methods of treating advanced malignancies are of high importance. Of these deaths, prostate cancer and breast cancer are the second most fatal carcinomas in men and women respectively, while pancreatic cancer is the fourth most fatal in both men and women. Developing new drugs for the treatment of cancer is both a slow and expensive process. It is estimated that it takes an average of 15 years and an expense of $800 million to bring a single new drug to the market. However, it is also estimated that nearly 40% of that cost could be avoided by finding alternative uses for drugs that have already been approved by the Food and Drug Administration (FDA). The research pre... (more)
Created Date 2013
Contributor Taylor, David (Author) / Rege, Kaushal (Advisor) / Jayaraman, Arul (Committee member) / Nielsen, David (Committee member) / Kodibagkar, Vikram (Committee member) / Dai, Lenore (Committee member) / Arizona State University (Publisher)
Subject Chemical engineering / Biomedical engineering / Cellular biology / Apoptosis / Cancer / FDA-Approved / Microfluidic Device / Mitoxantrone / TRAIL
Type Doctoral Dissertation
Extent 215 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Chemical Engineering 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis