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Rotating Live Mammalian Cells Free in Media Using Spatial Light Modulator (SLM)-Generated Optical Tweezers

Abstract In the frenzy of next generation genetic sequencing and proteomics, single-cell level analysis has begun to find its place in the crux of personalized medicine and cancer research. Single live cell 3D imaging technology is one of the most useful ways of providing spatial and morphological details inside living single cells. It provides a window to uncover the mysteries of protein structure and folding, as well as genetic expression over time, which will tremendously improve the state of the fields of biophysics and biomedical research. This thesis project specifically demonstrates a method for live single cell rotation required to image them in the single live cell CT imaging platform. The method of rotation proposed in this thesis uses dyn... (more)
Created Date 2013
Contributor Chan, Samantha Wan Yu (Author) / Meldrum, Deridre R (Advisor) / Kleim, Jeffrey A (Committee member) / Johnson, Roger H (Committee member) / Kelbauskas, Laimonas (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Optics / holography / laser / optical trap / optical tweezer / rotation / spatial light modulator
Type Masters Thesis
Extent 94 pages
Language English
Reuse Permissions All Rights Reserved
Note M.S. Bioengineering 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis