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Individualizing the Informed Consent Process for Whole Genome Sequencing: A Patient Directed Approach


Abstract ABSTRACT Whole genome sequencing (WGS) and whole exome sequencing (WES) are two comprehensive genomic tests which use next-generation sequencing technology to sequence most of the 3.2 billion base pairs in a human genome (WGS) or many of the estimated 22,000 protein-coding genes in the genome (WES). The promises offered from WGS/WES are: to identify suspected yet unidentified genetic diseases, to characterize the genomic mutations in a tumor to identify targeted therapeutic agents and, to predict future diseases with the hope of promoting disease prevention strategies and/or offering early treatment. Promises notwithstanding, sequencing a human genome presents several interrelated challenges: how to adequately analyze, interpret, store, rea... (more)
Created Date 2013
Contributor Hunt, Katherine Susan (Author) / Hurlbut, J. Benjamin (Advisor) / Robert, Jason S. (Advisor) / Maienschein, Jane (Committee member) / Northfelt, Donald W. (Committee member) / Marchant, Gary (Committee member) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Subject Medical ethics / Genetics / Genetic counseling / Genome sequencing / Individualized consent / Informed consent / Personalized medicine
Type Doctoral Dissertation
Extent 212 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Biology 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis