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Bleomycin, From Start to Finish; Total Synthesis of Novel Analogues to in vitro Fluorescence Microscopy Imaging


Abstract The bleomycins are a family of glycopeptide-derived antibiotics isolated from various Streptomyces species and have been the subject of much attention from the scientific community as a consequence of their antitumor activity. Bleomycin clinically and is an integral part of a number of combination chemotherapy regimens. It has previously been shown that bleomycin has the ability to selectively target tumor cells over their non-malignant counterparts. Pyrimidoblamic acid, the N-terminal metal ion binding domain of bleomycin is known to be the moiety that is responsible for O2 activation and the subsequent chemistry leading to DNA strand scission and overall antitumor activity. Chapter 1 describes bleomycin and related DNA targeting antitumor... (more)
Created Date 2013
Contributor Bozeman, Trevor (Author) / Hecht, Sidney M (Advisor) / Chaput, John (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Biochemistry / Pharmaceutical sciences / Bleomycin / Bozeman / cancer / Fluorescence Microscopy / Pyrimidoblamic acid / Surface Plasmon Resonance
Type Doctoral Dissertation
Extent 152 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Chemistry 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis