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Expression of Dengue virus envelope glycoproteins using a Measles vaccine vector


Abstract ABSTRACT In terms of prevalence, human suffering and costs dengue infections are the most important arthropod-borne viral disease worldwide. Dengue virus (DENV) is a mosquito-borne flavivirus and the etiological agent of dengue fever and dengue hemorrhagic fever. Thus, development of a safe and efficient vaccine constitutes an urgent necessity. Besides the traditional strategies aim at generating immunization options, the usage of viral vectors to deliver antigenic stimulus in order to elicit protection are particularly attractive for the endeavor of a dengue vaccine. The viral vector (MVvac2) is genetically equivalent to the currently used measles vaccine strain Moraten, which adds practicality to my approach. The goal of the present study... (more)
Created Date 2013
Contributor Abdelgalel, Rowida (Author) / Reyes Del Valle, Jorge (Advisor) / Hogue, Brenda (Committee member) / Frasch, Wayne D (Committee member) / Arizona State University (Publisher)
Subject Virology / Microbiology / Molecular biology / Dengue vaccine / Divalent vaccine / Flavivirus vaccine / Measles vaccine / Recombinant Dengue vaccine
Type Masters Thesis
Extent 123 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Biology 2013
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis