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Evaluating and Controlling Glioblastoma Infiltration

Abstract Glioblastoma (GBM) is the most common primary brain tumor with an incidence of approximately 11,000 Americans. Despite decades of research, average survival for GBM patients is a modest 15 months. Increasing the extent of GBM resection increases patient survival. However, extending neurosurgical margins also threatens the removal of eloquent brain. For this reason, the infiltrative nature of GBM is an obstacle to its complete resection. We hypothesize that targeting genes and proteins that regulate GBM motility, and developing techniques that safely enhance extent of surgical resection, will improve GBM patient survival by decreasing infiltration into eloquent brain regions and enhancing tumor cytoreduction during surgery. Chapter 2 of this... (more)
Created Date 2014
Contributor Georges, Joseph (Author) / Feuerstein, Burt G (Advisor) / Smith, Brian H (Advisor) / Van Keuren-Jensen, Kendall (Committee member) / Deviche, Pierre (Committee member) / Bennett, Kevin (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Oncology / Medical imaging and radiology / Aquaporin / Barrow / Confocal / Fluorescence / Glioblastoma / Neurosurgery
Type Doctoral Dissertation
Extent 143 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Neuroscience 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis