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Toxicity study in Alzheimer's disease cell model


Abstract Alzheimer's disease (AD) is the most common type of dementia, affecting one in nine people age 65 and older. One of the most important neuropathological characteristics of Alzheimer's disease is the aggregation and deposition of the protein beta-amyloid. Beta-amyloid is produced by proteolytic processing of the Amyloid Precursor Protein (APP). Production of beta-amyloid from APP is increased when cells are subject to stress since both APP and beta-secretase are upregulated by stress. An increased beta-amyloid level promotes aggregation of beta-amyloid into toxic species which cause an increase in reactive oxygen species (ROS) and a decrease in cell viability. Therefore reducing beta-amyloid generation is a promising method to contro... (more)
Created Date 2014
Contributor Suryadi, Vicky Rulando (Author) / Sierks, Michael (Advisor) / Nielsen, David (Committee member) / Dai, Lenore (Committee member) / Arizona State University (Publisher)
Subject Chemical engineering / Biomedical engineering / Alzheimer's disease / beta amyloid
Type Masters Thesis
Extent 54 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Chemical Engineering 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis