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In Vitro and In Vivo Assessment of the Mechanism of Action and Efficacy of Antibacterial Clays for the Treatment of Cutaneous Infections


Abstract The prevalence of antibiotic resistant bacterial pathogens has increased since the introduction of penicillin in the 1940s. Insufficient development of novel antibacterial agents is leaving us with a failing arsenal of therapies to combat these pathogenic organisms. We have identified a clay mineral mixture (designated CB) that exhibits in vitro antibacterial activity against a broad spectrum of bacterial pathogens, yet the antibacterial mechanism of action remains unknown. Antibacterial susceptibility testing of four different clay samples collected from the same source revealed that these natural clays had markedly different antibacterial activity. X-ray diffraction analyses of these minerals revealed minor mineralogical differences acros... (more)
Created Date 2014
Contributor Otto, Caitin Carol (Author) / Haydel, Shelley (Advisor) / Stout, Valerie (Committee member) / Roberson, Robby (Committee member) / Sandrin, Todd (Committee member) / Rege, Kaushal (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Antibacterial / Clay / MRSA / Natural products
Type Doctoral Dissertation
Extent 195 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Microbiology 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis