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Perturbing Neural Feedback Loops to Understand the Relationships of Their Parts


Abstract The basal ganglia are four sub-cortical nuclei associated with motor control and reward learning. They are part of numerous larger mostly segregated loops where the basal ganglia receive inputs from specific regions of cortex. Converging on these inputs are dopaminergic neurons that alter their firing based on received and/or predicted rewarding outcomes of a behavior. The basal ganglia's output feeds through the thalamus back to the areas of the cortex where the loop originated. Understanding the dynamic interactions between the various parts of these loops is critical to understanding the basal ganglia's role in motor control and reward based learning. This work developed several experimental techniques that can be applied to furt... (more)
Created Date 2014
Contributor Baldwin, Nathan A. (Author) / Helms Tillery, Stephen I (Advisor) / Castañeda, Edward (Committee member) / Buneo, Christopher A (Committee member) / Muthuswamy, Jitendran (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Neurosciences / basal ganglia / drug injections / reward learning / self-organizing maps / temporary lesions
Type Doctoral Dissertation
Extent 160 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Bioengineering 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis