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The Dissection of Signaling Cascades in Neural Stem Cell Proliferation & GBM Promotion


Abstract Cells live in complex environments and must be able to adapt to environmental changes in order to survive. The ability of a cell to survive and thrive in a changing environment depends largely on its ability to receive and respond to extracellular signals. Initiating with receptors, signal transduction cascades begin translating extracellular signals into intracellular messages. Such signaling cascades are responsible for the regulation of cellular metabolism, cell growth, cell movement, transcription, translation, proliferation and differentiation. This dissertation seeks to dissect and examine critical signaling pathways involved in the regulation of proliferation in neural stem cells (Chapter 2) and the regulation of Glioblastoma Multifo... (more)
Created Date 2014
Contributor Kusne, Yael N. (Author) / Sanai, Nader (Advisor) / Neisewander, Janet (Advisor) / Tran, Nhan (Committee member) / Hammer, Ronald (Committee member) / Narayanan, Vinodh (Committee member) / Shapiro, Joan (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Cellular biology / Molecular biology / aPKC / Glioblastoma / Neural Stem Cell
Type Doctoral Dissertation
Extent 194 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Neuroscience 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis