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Engineering Cyanobacteria to Convert Carbon Dioxide to Building Blocks for Renewable Plastics


Abstract The production of monomer compounds for synthesizing plastics has to date been largely restricted to the petroleum-based chemical industry and sugar-based microbial fermentation, limiting its sustainability and economic feasibility. Cyanobacteria have, however, become attractive microbial factories to produce renewable fuels and chemicals directly from sunlight and CO2. To explore the feasibility of photosynthetic production of (S)- and (R)-3-hydroxybutyrate (3HB), building-block monomers for synthesizing the biodegradable plastics polyhydroxyalkanoates and precursors to fine chemicals, synthetic metabolic pathways have been constructed, characterized and optimized in the cyanobacterium Synechocystis sp. PCC 6803 (hereafter Synechocystis 68... (more)
Created Date 2014
Contributor Wang, Bo (Author) / Meldrum, Deirdre R (Advisor) / Zhang, Weiwen (Committee member) / Sandrin, Todd R (Committee member) / Nielsen, David R (Committee member) / Arizona State University (Publisher)
Subject Chemical engineering / Molecular biology / Microbiology / 3-Hydroxybutyrate / Biofuel / Cyanobacterium / Metabolic engineering / Methylation / Synthetic biology
Type Doctoral Dissertation
Extent 155 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Ph.D. Biological Design 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis