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Transcriptome and Metabolic Profiling of Premalignant Progression in Barrett's Esophagus

Abstract Cell-cell interactions in a microenvironment under stress conditions play a critical role in pathogenesis and pre-malignant progression. Hypoxia is a central factor in carcinogenesis, which induces selective pressure in this process. Understanding the role of intercellular communications and cellular adaptation to hypoxia can help discover new cancer biosignatures and more effective diagnostic and therapeutic strategies. This dissertation presents a study on transcriptomic and metabolic profiling of pre-malignant progression of Barrett's esophagus. It encompasses two methodology developments and experimental findings of two related studies. To integrate phenotype and genotype measurements, a minimally invasive method was developed for s... (more)
Created Date 2014
Contributor Zeng, Jia (Author) / Meldrum, Deirdre R (Advisor) / Kelbauskas, Laimonas (Committee member) / Barrett, Michael T (Committee member) / Bussey, Kimberly J (Committee member) / Zhang, Weiwen (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Biomedical engineering / premalignant progression / single cell / transcriptome
Type Doctoral Dissertation
Extent 233 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Biological Design 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis