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Exploring the Nature of Protein-Peptide Interactions on Surfaces

Abstract Protein-surface interactions, no matter structured or unstructured, are important in both biological and man-made systems. Unstructured interactions are more difficult to study with conventional techniques due to the lack of a specific binding structure. In this dissertation, a novel approach is employed to study the unstructured interactions between proteins and heterogonous surfaces, by looking at a large number of different binding partners at surfaces and using the binding information to understand the chemistry of binding. In this regard, surface-bound peptide arrays are used as a model for the study. Specifically, in Chapter 2, the effects of charge, hydrophobicity and length of surface-bound peptides on binding affinity for specific ... (more)
Created Date 2014
Contributor Wang, Wei (Author) / Woodbury, Neal W (Advisor) / Liu, Yan (Committee member) / Chaput, John (Committee member) / Arizona State University (Publisher)
Subject Biochemistry / Bioinformatics / Molecular chemistry / Additive binding / Length Dependence / Non-specific interaction / Peptide-antibody interaction / Peptide microarray / Protein-surface interaction
Type Doctoral Dissertation
Extent 164 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biochemistry 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis