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Pathogen Origins and Evolution in the New World: A Molecular and Bioarchaeological Approach to Tuberculosis and Leishmaniasis

Abstract Studies of ancient pathogens are moving beyond simple confirmatory analysis of diseased bone; bioarchaeologists and ancient geneticists are posing nuanced questions and utilizing novel methods capable of confronting the debates surrounding pathogen origins and evolution, and the relationships between humans and disease in the past. This dissertation examines two ancient human diseases through molecular and bioarchaeological lines of evidence, relying on techniques in paleogenetics and phylogenetics to detect, isolate, sequence and analyze ancient and modern pathogen DNA within an evolutionary framework. Specifically this research addresses outstanding issues regarding a) the evolution, origin and phylogenetic placement of the pathogen causi... (more)
Created Date 2014
Contributor Harkins, Kelly Marie (Author) / Buikstra, Jane E (Advisor) / Stone, Anne C (Advisor) / Knudson, Kelly (Committee member) / Kumar, Sudhir (Committee member) / Krause, Johannes (Committee member) / Arizona State University (Publisher)
Subject Archaeology / Genetics / Bioarchaeology / Paleogenetics / Pathogen Origins and Evolution / Phylogenetics
Type Doctoral Dissertation
Extent 303 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Anthropology 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis