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Synthesis, Biochemical and Pharmacological Evaluation of Rationally Designed Multifunctional Radical Quenchers

Abstract Mitochondria are crucial intracellular organelles which play a pivotal role in providing energy to living organisms in the form of adenosine triphosphate (ATP). The mitochondrial electron transport chain (ETC) coupled with oxidative phosphorylation (OX-PHOS) transforms the chemical energy of amino acids, fatty acids and sugars to ATP. The mitochondrial electron transport system consumes nearly 90% of the oxygen used by the cell. Reactive oxygen species (ROS) in the form of superoxide anions (O2*-) are generated as byproduct of cellular metabolism due to leakage of electrons from complex I and complex III to oxygen. Under normal conditions, the effects of ROS are offset by a variety of antioxidants (enzymatic and non-enzymatic).

Mitochondr... (more)
Created Date 2014
Contributor Alam, Mohammad Parvez (Author) / Hecht, Sidney M (Advisor) / Gould, Ian R (Committee member) / Moore, Ana (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Organic chemistry
Type Doctoral Dissertation
Extent 206 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis