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Cortical Auditory Functional Activation By Cortico-Striato-Thalamo-Cortical Circuits


Auditory hallucinations are a characteristic symptom of schizophrenia. Research has documented that the auditory cortex is metabolically activated when this process occurs, and that imbalances in the dopaminergic transmission in the striatum contribute to its physiopathology. Most animal models have focused the effort on pharmacological approaches like non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists to produce activation of the auditory cortex, or dopamine antagonists to alleviate it. I hypothesize that these perceptual phenomena can be explained by an imbalance activation of spiny projecting neurons in the striatal pathways, whereby supersensitive postsynaptic D2-like receptor, signaling in the posterior cau... (more)
Created Date 2014
Contributor Parga Becerra, Alejandro (Author) / Neisewander, Janet (Advisor) / Hammer, Ronald (Advisor) / Gallitano-Mendel, Amelia (Committee member) / McLoone, Jim (Committee member) / Vu, Jie (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Pharmacology / Auditory Hallucinations / D2-like / Dopamine / PRV-152 / Striatum / Zif268
Type Doctoral Dissertation
Extent 105 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Neuroscience 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

  Full Text
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Description Dissertation/Thesis
  3D 48 h A14.MSWMM
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Description Figure 9C. 3D brain reconstruction after 48 hours of PRV-152 inoculations
  3D 24 h A2.MSWMM
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Description Figure 9A. 3D brain reconstruction after 24 h postinoculation
  3D 36 h A7.MSWMM
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Description Figure 9B. 3D brain reconstruction after 36 h postinoculation